Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yafN-yafO (relBE)/YafO-YafN
Location 3473209..3473903 Replicon chromosome
Accession NZ_CP057481
Organism Escherichia fergusonii strain RHB25-C10

Toxin (Protein)


Gene name yafO Uniprot ID -
Locus tag HVY20_RS16725 Protein ID WP_181665641.1
Coordinates 3473209..3473607 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name yafN Uniprot ID -
Locus tag HVY20_RS16730 Protein ID WP_181665642.1
Coordinates 3473610..3473903 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HVY20_RS16695 3468335..3469792 + 1458 WP_181665639.1 cytosol nonspecific dipeptidase -
HVY20_RS16700 3469801..3470082 + 282 WP_000106440.1 hypothetical protein -
HVY20_RS16705 3470091..3470615 - 525 WP_000469797.1 hypothetical protein -
HVY20_RS16710 3470678..3471292 - 615 WP_000602128.1 peptide chain release factor H -
HVY20_RS16715 3471289..3472428 - 1140 WP_181665640.1 RNA ligase RtcB family protein -
HVY20_RS16720 3472747..3473199 - 453 WP_001059848.1 GNAT family N-acetyltransferase -
HVY20_RS16725 3473209..3473607 - 399 WP_181665641.1 type II toxin-antitoxin system mRNA interferase toxin YafO Toxin
HVY20_RS16730 3473610..3473903 - 294 WP_181665642.1 type I toxin-antitoxin system antitoxin YafN Antitoxin
HVY20_RS16735 3473955..3475010 - 1056 WP_001226156.1 DNA polymerase IV -
HVY20_RS16740 3475081..3475866 - 786 WP_162754239.1 putative lateral flagellar export/assembly protein LafU -
HVY20_RS16745 3475811..3477550 + 1740 WP_181665643.1 flagellar biosynthesis protein FlhA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin YafO

(28-130)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 15408.83 Da        Isoelectric Point: 9.6253

>T165381 WP_181665641.1 NZ_CP057481:c3473607-3473209 [Escherichia fergusonii]
MRVFKTKLIRLQLTAKELDALTADFISSKRDGVLPDIFGRDALYDDSFTWPLIKFERVAHIHLANENNPFPPQLRQFSRT
NDEAHLVYCQGAFDEQVRLLIAILKPEPHKLARDNNQMHKIGKMAEAFRMRF

Download         Length: 399 bp

>T165381 NZ_CP073844:822397-822792 [Staphylococcus epidermidis]
ATGCAAAGCACTAAATATTTAACTGAAAAACAAGTGATTGCCATTAATGTAAAAGCAATACAAGATTTCTCACCAAAAGA
ACAAGTTGGTGTTAAAGTTCCAGAAGTTCTTAATGCTACTATTGAAGGAGTTAAACAATCATTCGGTGGAGTTGAACTAT
ATGAAACAATCGAGAGAAAAGCAGCTTTTATATATAGAAATATAGCTCAAAAGCACGCATTCCATAATGCGAATAAAAGA
ACAGCTTTTACATCTATGGTAATATTTTTGAAGTTAAATAGTATTAATTTTGAATGCACTCAAGATGAAGCGGTTCAGTT
TACTTTAAGAGTAGTAAACGACAAAAATCTTACTCTTGAGGGAATTGAGACATGGATCAAGAGGCATTGTAAATAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11257.74 Da        Isoelectric Point: 5.2170

>AT165381 WP_181665642.1 NZ_CP057481:c3473903-3473610 [Escherichia fergusonii]
MHRIFAEKSVNITELRKNPAKYFIDQPVAVLSNNRPAGYLLSASAFEALMDMLAEQEEKKSIKARFRPSAARLEEITRRA
EQYLNDMTDDDFNDFKE

Download         Length: 294 bp

>AT165381 NZ_CP073844:822167-822397 [Staphylococcus epidermidis]
ATGATTACTACAAGAAAACTAAGAAAAGCTGGTAATAGTTCAGTTGTTTCTGTACCGACAGAAGTGATCGCAGCACTCGG
AATATCAAATGGTGATAATCTTAAATTTAATGTAAAAGATAATAAAGTAACCATCGAAAAGGAGGTAAGAGAGGACGAGG
AGTTTTTTAAATTGTTGGATGAAACATTCACTGAGTATAACCAAGCTTTAAAAAGGATGGTTGACTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References