Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 2776228..2776730 Replicon chromosome
Accession NZ_CP057481
Organism Escherichia fergusonii strain RHB25-C10

Toxin (Protein)


Gene name yoeB Uniprot ID U9YDH0
Locus tag HVY20_RS13225 Protein ID WP_000767829.1
Coordinates 2776228..2776482 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag HVY20_RS13230 Protein ID WP_001259255.1
Coordinates 2776479..2776730 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HVY20_RS13195 2771244..2771471 - 228 WP_000985273.1 sulfurtransferase TusA family protein -
HVY20_RS13200 2771485..2772543 - 1059 WP_181665469.1 transport protein YeeE -
HVY20_RS13205 2772722..2774080 - 1359 WP_000019201.1 putrescine/proton symporter PlaP -
HVY20_RS13210 2774070..2774132 - 63 WP_010723108.1 membrane protein YoeI -
HVY20_RS13215 2774346..2775275 - 930 WP_000803361.1 LysR family transcriptional regulator -
HVY20_RS13220 2775321..2776145 - 825 WP_181665470.1 SDR family oxidoreductase -
HVY20_RS13225 2776228..2776482 - 255 WP_000767829.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
HVY20_RS13230 2776479..2776730 - 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
HVY20_RS13235 2777014..2777064 + 51 WP_001364200.1 his operon leader peptide -
HVY20_RS13240 2777210..2778109 + 900 WP_000131779.1 ATP phosphoribosyltransferase -
HVY20_RS13245 2778115..2779419 + 1305 WP_181665471.1 histidinol dehydrogenase -
HVY20_RS13250 2779416..2780486 + 1071 WP_000108922.1 histidinol-phosphate transaminase -
HVY20_RS13255 2780486..2781553 + 1068 WP_181665472.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T165379 WP_000767829.1 NZ_CP057481:c2776482-2776228 [Escherichia fergusonii]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

>T165379 NZ_CP073844:682087-682296 [Staphylococcus epidermidis]
ATGAAATTGAAAAAAGGATTGATAAATGTTTCAGGTATTAAAACAACTGAACAAGCTAAACAGCTCAAAGATCATTTATC
TAAGATGATAGGCATCAATAGTGTGGATATCGATTACCAAATGAATGAGATTCGAGTAGAATTTGACACTCCTGCAAATT
TAAATAACATTGAAAAAGAAATTTACGATTACGGATTTCGTATTTTGTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT165379 WP_001259255.1 NZ_CP057481:c2776730-2776479 [Escherichia fergusonii]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp

>AT165379 NZ_CP073844:681787-682080 [Staphylococcus epidermidis]
ATGGCAGACATGGAGAGTGCACATCACTCAGAGCAAATAAAAACAAATTTAAAATCAAGATTAAATAGAATAGAAGGTCA
AGTAAGAGCAATAAATCGTATGATTGATGATGACGTTTACTGTGATGATGTACTAACTCAAATTAGAGCAACACGTTCAG
CATTGAATAGTGTAGCTACTAAATTACTAGACCATCACATGAAAGGTTGTATTATGGAAAAAATAAACGACGGTGCGCAA
GAAGAAGCAATGGATGAATTGCTCGTGACATTCCAAAAATTAATAAAAGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6NY6
PDB 2A6S
PDB 6OXA
PDB 2A6R
PDB 4V8X
PDB 6OTR
PDB 6OXI
PDB 2A6Q

Antitoxin

Source ID Structure
PDB 2A6Q
AlphaFold DB A0A7U9LNR0

References