Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 2195319..2195881 Replicon chromosome
Accession NZ_CP057481
Organism Escherichia fergusonii strain RHB25-C10

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag HVY20_RS10400 Protein ID WP_000605678.1
Coordinates 2195603..2195881 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID S1PAQ1
Locus tag HVY20_RS10395 Protein ID WP_000781370.1
Coordinates 2195319..2195603 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HVY20_RS10380 2190678..2193725 + 3048 WP_015912497.1 formate dehydrogenase-N subunit alpha -
HVY20_RS10385 2193738..2194622 + 885 WP_180491791.1 formate dehydrogenase N subunit beta -
HVY20_RS10390 2194615..2195268 + 654 WP_000045648.1 formate dehydrogenase-N subunit gamma -
HVY20_RS10395 2195319..2195603 - 285 WP_000781370.1 HigA family addiction module antidote protein Antitoxin
HVY20_RS10400 2195603..2195881 - 279 WP_000605678.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HVY20_RS10405 2196067..2197077 - 1011 WP_000642407.1 alcohol dehydrogenase AdhP -
HVY20_RS10410 2197212..2198909 - 1698 WP_181203469.1 malate dehydrogenase -
HVY20_RS10415 2199066..2199203 - 138 WP_000841554.1 stationary-phase-induced ribosome-associated protein -
HVY20_RS10420 2199305..2199520 - 216 WP_000495766.1 biofilm-dependent modulation protein -
HVY20_RS10425 2199862..2200293 + 432 WP_000152299.1 peroxiredoxin OsmC -
HVY20_RS10430 2200354..2200494 + 141 WP_114091452.1 omptin family outer membrane protease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-88)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10478.07 Da        Isoelectric Point: 6.8675

>T165378 WP_000605678.1 NZ_CP057481:c2195881-2195603 [Escherichia fergusonii]
MIMNFRHKGLRDLFLLGKTSGVIPTQVKRLRHRLAVIDAASCLADLDMPGYRLHPLSGDRDGIWAISVSGNWLITFEFVN
GDAYILDYEDYH

Download         Length: 279 bp

>T165378 NZ_CP073844:c467488-467300 [Staphylococcus epidermidis]
ATGAGCTTACATTTCCAAATTTTGCTGTGGCTTTCTATCTTATTTATCATCGCAGGAACGATATTATTGGTAACAATGCT
TAAAACTAAAAAAGAAGAACGAAAAGAATCTTATCTAGGCTTTACTGTAATTTTCTTAATCTTTGGTTTTGCCATCTTAA
TTTATACTTTTATATTCGGAATTTTATAA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10401.08 Da        Isoelectric Point: 8.8567

>AT165378 WP_000781370.1 NZ_CP057481:c2195603-2195319 [Escherichia fergusonii]
MKMANHPRPGDIIQESLDELNVSLREFARAMEIAPSTASRLLTGKAALTPEMAIKLSVVIGSSPQMWLNLQNAWSLAEAE
KTVDVSRLRRLVTQ

Download         Length: 285 bp

>AT165378 NZ_CP073844:c467770-467513 [Staphylococcus epidermidis]
ATGAAATTAAACAAAGCAAATATATTCAATTTGATATTCACCATTTTATTTTTTTCATTTAACATTCTCATAACCTATAA
CGCAAATATAGATTATAAGTTATGGTTAATACCTGGTTTAGCAATTTGTGGTTTTGCTCTTTTTTCAAGCTTGACCTTAG
TAATTATCTATAGTGATTTATTCAGTGAAATATTATTTTTTATCAACATTATCTTAGCACTGTATTACATTTATCCGATT
TTTTATGAATTTGTCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 2ICT
PDB 2ICP
AlphaFold DB A0A829CUG6

References