Detailed information of TA system TA165366

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 1032845..1033091
• Replicon: chromosome
• Accession: NZ_CP057481
• Organism: Escherichia fergusonii strain RHB25-C10

Toxin (Protein)

• Gene name: hokX
• Uniprot ID: S1PD89
• Locus tag: HVY20_RS04990
• Protein ID: WP_000956458.1
• Coordinates: 1032939..1033091 (+)
• Length: 51 a.a.

Antitoxin (RNA)

Gene name	sokX
Locus tag	-
Coordinates	1032845..1032897 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HVY20_RS04975	1028353..1030152	+	1800	WP_181666033.1	NADPH-dependent assimilatory sulfite reductase flavoprotein subunit	-
HVY20_RS04980	1030152..1031864	+	1713	WP_181666034.1	assimilatory sulfite reductase (NADPH) hemoprotein subunit	-
HVY20_RS04985	1031938..1032672	+	735	WP_181666035.1	phosphoadenosine phosphosulfate reductase	-
-	1032845..1032897	-	53	-	-	Antitoxin
HVY20_RS04990	1032939..1033091	+	153	WP_000956458.1	type I toxin-antitoxin system Hok family toxin	Toxin
HVY20_RS04995	1033327..1035984	+	2658	WP_002431960.1	CRISPR-associated helicase/endonuclease Cas3	-
HVY20_RS05000	1036082..1037644	+	1563	WP_181203171.1	type I-E CRISPR-associated protein Cse1/CasA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (5-46)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5558.77 Da
• Isoelectric Point: 7.6757

>T165366 WP_000956458.1 NZ_CP057481:1032939-1033091 [Escherichia fergusonii]
MLTKYALVAIIVLCCTVLGFTLMVGDSLCELSIRERGMEFKAVLAYESKK

Nucleotide

• Length: 153 bp

>T165366 NZ_CP073836:822590-822985 [Staphylococcus epidermidis]
ATGCAAAGCACTAAATATTTAACTGAAAAACAAGTGATTGCCATTAATGTAAAAGCAATACAAGATTTCTCACCAAAAGA
ACAAGTTGGTGTTAAAGTTCCAGAAGTTCTTAATGCTACTATTGAAGGAGTTAAACAATCATTCGGTGGAGTTGAACTAT
ATGAAACAATCGAGAGAAAAGCAGCTTTTATATATAGAAATATAGCTCAAAAGCACGCATTCCATAATGCGAATAAAAGA
ACAGCTTTTACATCTATGGTAATATTTTTGAAGTTAAATAGTATTAATTTTGAATGCACTCAAGATGAAGCGGTTCAGTT
TACTTTAAGAGTAGTAAACGACAAAAATCTTACTCTTGAGGGAATTGAGACATGGATCAAGAGGCATTGTAAATAA

Antitoxin

Nucleotide

• Length: 53 bp

>AT165366 NZ_CP057481:c1032897-1032845 [Escherichia fergusonii]
TTAGGTTCGAACGCTGGCCTCAGGTTGATAGAAATATCGCCTGGGGCTTTTGT

Structures

Toxin

• AlphaFold DB: A0A4P7TJ83

Antitoxin