Detailed information of TA system TA165363

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 729555..729813
• Replicon: chromosome
• Accession: NZ_CP057481
• Organism: Escherichia fergusonii strain RHB25-C10

Toxin (Protein)

• Gene name: hokC
• Uniprot ID: -
• Locus tag: HVY20_RS03610
• Protein ID: WP_000935262.1
• Coordinates: 729555..729764 (-)
• Length: 70 a.a.

Antitoxin (RNA)

Gene name	sokC
Locus tag	-
Coordinates	729756..729813 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HVY20_RS03590	724621..725208	+	588	WP_046083027.1	molybdopterin adenylyltransferase	-
HVY20_RS03595	725242..725808	-	567	WP_000528529.1	acetate uptake transporter	-
HVY20_RS03600	726316..728232	+	1917	WP_000516135.1	molecular chaperone DnaK	-
HVY20_RS03605	728321..729451	+	1131	WP_001118464.1	molecular chaperone DnaJ	-
HVY20_RS03610	729555..729764	-	210	WP_000935262.1	type I toxin-antitoxin system Hok family toxin	Toxin
-	729756..729813	+	58	-	-	Antitoxin
HVY20_RS03615	730248..731414	+	1167	WP_046076806.1	Na+/H+ antiporter NhaA	-
HVY20_RS03620	731482..732381	+	900	WP_000019050.1	transcriptional activator NhaR	-
HVY20_RS03625	732477..732740	-	264	WP_001274021.1	30S ribosomal protein S20	-
HVY20_RS03630	732843..733061	+	219	WP_001353471.1	DUF2575 family protein	-
HVY20_RS03635	733069..734010	+	942	WP_000767329.1	bifunctional riboflavin kinase/FAD synthetase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (25-66)

Sequences

Toxin

Protein

• Length: 70 a.a.
• Molecular weight: 7742.28 Da
• Isoelectric Point: 9.3680

>T165363 WP_000935262.1 NZ_CP057481:c729764-729555 [Escherichia fergusonii]
MLNTCRVPLTDRKVKEKRAMKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Nucleotide

• Length: 210 bp

>T165363 NZ_CP073836:c467681-467493 [Staphylococcus epidermidis]
ATGAGCTTACATTTCCAAATTTTGCTGTGGCTTTCTATCTTATTTATCATCGCAGGAACGATATTATTGGTAACAATGCT
TAAAACTAAAAAAGAAGAACGAAAAGAATCTTATCTAGGCTTTACTGTAATTTTCTTAATCTTTGGTTTTGCCATCTTAA
TTTATACTTTTATATTCGGAATTTTATAA

Antitoxin

Nucleotide

• Length: 58 bp

>AT165363 NZ_CP057481:729756-729813 [Escherichia fergusonii]
GTTCAGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Structures

Antitoxin