Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HTH_XRE
Location 4086561..4087240 Replicon chromosome
Accession NZ_CP057463
Organism Escherichia fergusonii strain RHB26-C03

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag HVY27_RS20080 Protein ID WP_181198810.1
Coordinates 4086561..4086863 (+) Length 101 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag HVY27_RS20085 Protein ID WP_000806441.1
Coordinates 4086899..4087240 (+) Length 114 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HVY27_RS20055 4081937..4083589 + 1653 WP_160193899.1 bifunctional UDP-sugar hydrolase/5'-nucleotidase -
HVY27_RS20060 4083627..4084130 - 504 WP_000667001.1 hypothetical protein -
HVY27_RS20065 4084127..4084927 - 801 WP_181198808.1 hypothetical protein -
HVY27_RS20070 4084951..4085430 - 480 WP_181198809.1 Cys-tRNA(Pro)/Cys-tRNA(Cys) deacylase YbaK -
HVY27_RS20075 4085634..4086428 - 795 WP_046081753.1 TraB/GumN family protein -
HVY27_RS20080 4086561..4086863 + 303 WP_181198810.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HVY27_RS20085 4086899..4087240 + 342 WP_000806441.1 HigA family addiction module antidote protein Antitoxin
HVY27_RS20090 4087354..4089858 - 2505 WP_181198811.1 copper-exporting P-type ATPase CopA -
HVY27_RS20095 4090165..4091454 + 1290 WP_000102764.1 APC family permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(9-98)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-69)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11753.34 Da        Isoelectric Point: 10.3339

>T165355 WP_181198810.1 NZ_CP057463:4086561-4086863 [Escherichia fergusonii]
MAQKNNIRSFRDAWLADFFVHSTPHRKIPAEIHTTLSRKLDIINAATSHRDLRSPPGNRYEELSGKLQEYSSIRVNKQYR
LIFKWVNGKAAELYLDPHNY

Download         Length: 303 bp

>T165355 NZ_CP073830:c2022558-2022196 [Staphylococcus epidermidis]
ATGATTAGAAGAGGAGATGTTTATTTAGCGGATTTATCACCAGTTCAAGGGTCTGAACAAGGGGGAGTAAGACCTGTAGT
TATCATTCAAAATGATACTGGTAATAAATATAGTCCAACTGTAATTGTAGCTGCGATTACTGGTAGGATTAATAAAGCGA
AAATACCAACCCACGTAGAAATTGAAAAGAAAAAGTATAAATTAGACAAAGATTCAGTTATTCTTCTTGAACAAATTAGA
ACACTAGATAAAAAGCGTTTAAAAGAAAAATTAACATTTTTATCAGAGAGTAAAATGATAGAGGTTGATAATGCCTTAGA
TATTAGTTTGGGATTAAATAACTTTGATCATCATAAATCTTAA

Antitoxin


Download         Length: 114 a.a.        Molecular weight: 13143.01 Da        Isoelectric Point: 5.2345

>AT165355 WP_000806441.1 NZ_CP057463:4086899-4087240 [Escherichia fergusonii]
MKQATRKPTTPGDILLYEYLEPLDLKINELAELLHVHRNSVSALINNNRKLTTEMAFRLAKVFDTTVDFWLNLQAAVDLW
EVENNMRTQEELGRIETVADYLARREERAKNVA

Download         Length: 342 bp

>AT165355 NZ_CP073830:c2022725-2022555 [Staphylococcus epidermidis]
ATGTTATCTTTTAATCAAAATAGAAACCACAGTCTTGAACAATCTTTAAAAGAAGGTTATGCACAAATGGCCGATTTAAA
CCTCTCCCTAGCAACAGAAGCTTTTCCGATAGAGTGTGAAGCTTGTGATTGCAATGAATCACATTTAATATCTAATTCAA
AGAATGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References