Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 3867977..3868223 Replicon chromosome
Accession NZ_CP057463
Organism Escherichia fergusonii strain RHB26-C03

Toxin (Protein)


Gene name hokX Uniprot ID S1PD89
Locus tag HVY27_RS18975 Protein ID WP_000956458.1
Coordinates 3868071..3868223 (+) Length 51 a.a.

Antitoxin (RNA)


Gene name sokX
Locus tag -
Coordinates 3867977..3868029 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HVY27_RS18960 3863485..3865284 + 1800 WP_181198774.1 NADPH-dependent assimilatory sulfite reductase flavoprotein subunit -
HVY27_RS18965 3865284..3866996 + 1713 WP_046083135.1 assimilatory sulfite reductase (NADPH) hemoprotein subunit -
HVY27_RS18970 3867070..3867804 + 735 WP_046083134.1 phosphoadenosine phosphosulfate reductase -
- 3867977..3868029 - 53 - - Antitoxin
HVY27_RS18975 3868071..3868223 + 153 WP_000956458.1 type I toxin-antitoxin system Hok family toxin Toxin
HVY27_RS18980 3868459..3871116 + 2658 WP_181198775.1 CRISPR-associated helicase Cas3' -
HVY27_RS18985 3871582..3873144 + 1563 WP_104920139.1 type I-E CRISPR-associated protein Cse1/CasA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(5-46)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5558.77 Da        Isoelectric Point: 7.6757

>T165353 WP_000956458.1 NZ_CP057463:3868071-3868223 [Escherichia fergusonii]
MLTKYALVAIIVLCCTVLGFTLMVGDSLCELSIRERGMEFKAVLAYESKK

Download         Length: 153 bp

>T165353 NZ_CP073830:c1690859-1690680 [Staphylococcus epidermidis]
ATGGCGAACAAAAAAGATTCCAAATTAAATTATCATGAAGAAGAAAATGCTATGGTTACCGACTTAGATGATTTAAAAGA
ATTAGGAAAAGAAATGGAACAGATTTCACAGGAAAATGATGAAGAAAAATTAAATCAATCTCATGATAACGAAGTTCGTT
CAGATTTAAAAAAACAGTAA

Antitoxin


Download         Length: 53 bp

>AT165353 NZ_CP057463:c3868029-3867977 [Escherichia fergusonii]
TTAGGTTCGAACGCTGGCCTCAGGTTGATAGAAATATCGCCTGGGGCTTTTGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4P7TJ83

Antitoxin

Download structure file

References