Detailed information of TA system TA165349

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 3566661..3566919
• Replicon: chromosome
• Accession: NZ_CP057463
• Organism: Escherichia fergusonii strain RHB26-C03

Toxin (Protein)

• Gene name: hokC
• Uniprot ID: -
• Locus tag: HVY27_RS17600
• Protein ID: WP_181198725.1
• Coordinates: 3566661..3566870 (-)
• Length: 70 a.a.

Antitoxin (RNA)

Gene name	sokC
Locus tag	-
Coordinates	3566862..3566919 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HVY27_RS17580	3561726..3562313	+	588	WP_002431696.1	molybdopterin adenylyltransferase	-
HVY27_RS17585	3562347..3562913	-	567	WP_000528529.1	acetate uptake transporter	-
HVY27_RS17590	3563421..3565337	+	1917	WP_000516135.1	molecular chaperone DnaK	-
HVY27_RS17595	3565426..3566556	+	1131	WP_001118464.1	molecular chaperone DnaJ	-
HVY27_RS17600	3566661..3566870	-	210	WP_181198725.1	type I toxin-antitoxin system Hok family toxin	Toxin
-	3566862..3566919	+	58	-	-	Antitoxin
HVY27_RS17605	3567354..3568520	+	1167	WP_000681374.1	Na+/H+ antiporter NhaA	-
HVY27_RS17610	3568588..3569487	+	900	WP_000019049.1	transcriptional activator NhaR	-
HVY27_RS17615	3569583..3569846	-	264	WP_001274021.1	30S ribosomal protein S20	-
HVY27_RS17620	3569949..3570167	+	219	WP_181198726.1	DUF2575 domain-containing protein	-
HVY27_RS17625	3570175..3571116	+	942	WP_046081994.1	bifunctional riboflavin kinase/FAD synthetase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (25-66)

Sequences

Toxin

Protein

• Length: 70 a.a.
• Molecular weight: 7742.28 Da
• Isoelectric Point: 9.3680

>T165349 WP_181198725.1 NZ_CP057463:c3566870-3566661 [Escherichia fergusonii]
MLNTCRVPLTDRKVKEKRAMKQHKAMIVALIVICVTAIVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Nucleotide

• Length: 210 bp

>T165349 NZ_CP073827:c1892824-1892429 [Staphylococcus epidermidis]
ATGCAAAGCACTAAATATTTAACTGAAAAACAAGTGATTGCCATTAATGTAAAAGCAATACAAGATTTCTCACCAAAAGA
ACAAGTTGGTGTTAAAGTTCCAGAAGTTCTTAATGCTACTATTGAAGGAGTTAAACAATCATTCGGTGGAGTTGAACTAT
ATGAAACAATCGAGAGAAAAGCAGCTTTTATATATAGAAATATAGCTCAAAAGCACGCATTCCATAATGCGAATAAAAGA
ACAGCTTTTACATCTATGGTAATATTTTTGAAGTTAAATAGTATTAATTTTGAATGCACTCAAGATGAAGCGGTTCAGTT
TACTTTAAGAGTAGTAAACGACAAAAATCTTACTCTTGAGGGAATTGAGACATGGATCAAGAGGCATTGTAAATAA

Antitoxin

Nucleotide

• Length: 58 bp

>AT165349 NZ_CP057463:3566862-3566919 [Escherichia fergusonii]
GTTCAGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Structures

Antitoxin