Detailed information of TA system TA165346

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 2640698..2640955
• Replicon: chromosome
• Accession: NZ_CP057463
• Organism: Escherichia fergusonii strain RHB26-C03

Toxin (Protein)

• Gene name: hokA
• Uniprot ID: F4T5C6
• Locus tag: HVY27_RS13040
• Protein ID: WP_001135731.1
• Coordinates: 2640698..2640850 (-)
• Length: 51 a.a.

Antitoxin (RNA)

Gene name	sokA
Locus tag	-
Coordinates	2640907..2640955 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HVY27_RS13015	2636564..2637274	-	711	WP_000190514.1	DUF3053 domain-containing protein	-
HVY27_RS13020	2637712..2639082	+	1371	WP_104920428.1	MFS transporter	-
HVY27_RS13025	2639332..2639622	+	291	WP_000455800.1	HTH-type transcriptional regulator	-
HVY27_RS13030	2639903..2640115	+	213	WP_000014594.1	RNA chaperone/antiterminator CspA	-
HVY27_RS13035	2640169..2640540	-	372	WP_104920427.1	membrane protein insertion efficiency factor YidD	-
HVY27_RS13040	2640698..2640850	-	153	WP_001135731.1	type I toxin-antitoxin system toxin HokA	Toxin
-	2640907..2640955	+	49	-	-	Antitoxin
HVY27_RS13045	2641172..2643241	-	2070	WP_001291786.1	glycine--tRNA ligase subunit beta	-
HVY27_RS13050	2643251..2644162	-	912	WP_001168544.1	glycine--tRNA ligase subunit alpha	-
HVY27_RS13055	2644258..2644557	-	300	WP_024256552.1	YsaB family lipoprotein	-
HVY27_RS13060	2644729..2645724	+	996	WP_181198556.1	acyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (5-46)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 6025.30 Da
• Isoelectric Point: 7.7169

>T165346 WP_001135731.1 NZ_CP057463:c2640850-2640698 [Escherichia fergusonii]
MPQKYRLLSLIVICFTLLFFTWMIRDSLCELHIKQENYELAAFLACKLKE

Nucleotide

• Length: 153 bp

>T165346 NZ_CP073824:819938-820333 [Staphylococcus epidermidis]
ATGCAAAGCACTAAATATTTAACTGAAAAACAAGTGATTGCCATTAATGTAAAAGCAATACAAGATTTCTCACCAAAAGA
ACAAGTTGGTGTTAAAGTTCCAGAAGTTCTTAATGCTACTATTGAAGGAGTTAAACAATCATTCGGTGGAGTTGAACTAT
ATGAAACAATCGAGAGAAAAGCAGCTTTTATATATAGAAATATAGCTCAAAAGCACGCATTCCATAATGCGAATAAAAGA
ACAGCTTTTACATCTATGGTAATATTTTTGAAGTTAAATAGTATTAATTTTGAATGCACTCAAGATGAAGCGGTTCAGTT
TACTTTAAGAGTAGTAAACGACAAAAATCTTACTCTTGAGGGAATTGAGACATGGATCAAGAGGCATTGTAAATAA

Antitoxin

Nucleotide

• Length: 49 bp

>AT165346 NZ_CP057463:2640907-2640955 [Escherichia fergusonii]
GCATAGAGGGGCCTCACTTTGATTTATAGTCAGGTGGGGCTTTTCTCTG

Structures

Toxin

• AlphaFold DB: A0A061YDD9

Antitoxin