Detailed information of TA system TA165344

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): ldrD-ohsC/Ldr(toxin)
• Location: 2611519..2611738
• Replicon: chromosome
• Accession: NZ_CP057463
• Organism: Escherichia fergusonii strain RHB26-C03

Toxin (Protein)

• Gene name: ldrD
• Uniprot ID: A0A826RQE3
• Locus tag: HVY27_RS12905
• Protein ID: WP_000170746.1
• Coordinates: 2611519..2611626 (-)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	ohsC
Locus tag	-
Coordinates	2611675..2611738 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HVY27_RS12880	2606755..2607522	-	768	WP_181198551.1	cellulose biosynthesis protein BcsQ	-
HVY27_RS12885	2607534..2607722	-	189	WP_001063310.1	YhjR family protein	-
HVY27_RS12890	2608009..2609568	+	1560	WP_001070267.1	cellulose biosynthesis protein BcsE	-
HVY27_RS12895	2609565..2609756	+	192	WP_000981122.1	cellulose biosynthesis protein BcsF	-
HVY27_RS12900	2609753..2611432	+	1680	WP_000192007.1	cellulose biosynthesis protein BcsG	-
HVY27_RS12905	2611519..2611626	-	108	WP_000170746.1	type I toxin-antitoxin system toxin Ldr family protein	Toxin
-	2611675..2611738	+	64	NuclAT_13	-	Antitoxin
-	2611675..2611738	+	64	NuclAT_13	-	Antitoxin
-	2611675..2611738	+	64	NuclAT_13	-	Antitoxin
-	2611675..2611738	+	64	NuclAT_13	-	Antitoxin
-	2611675..2611738	+	64	NuclAT_14	-	Antitoxin
-	2611675..2611738	+	64	NuclAT_14	-	Antitoxin
-	2611675..2611738	+	64	NuclAT_14	-	Antitoxin
-	2611675..2611738	+	64	NuclAT_14	-	Antitoxin
-	2611675..2611738	+	64	NuclAT_15	-	Antitoxin
-	2611675..2611738	+	64	NuclAT_15	-	Antitoxin
-	2611675..2611738	+	64	NuclAT_15	-	Antitoxin
-	2611675..2611738	+	64	NuclAT_15	-	Antitoxin
-	2611675..2611738	+	64	NuclAT_16	-	Antitoxin
-	2611675..2611738	+	64	NuclAT_16	-	Antitoxin
-	2611675..2611738	+	64	NuclAT_16	-	Antitoxin
-	2611675..2611738	+	64	NuclAT_16	-	Antitoxin
-	2611675..2611740	+	66	NuclAT_10	-	-
-	2611675..2611740	+	66	NuclAT_10	-	-
-	2611675..2611740	+	66	NuclAT_10	-	-
-	2611675..2611740	+	66	NuclAT_10	-	-
-	2611675..2611740	+	66	NuclAT_11	-	-
-	2611675..2611740	+	66	NuclAT_11	-	-
-	2611675..2611740	+	66	NuclAT_11	-	-
-	2611675..2611740	+	66	NuclAT_11	-	-
HVY27_RS12910	2612062..2613258	+	1197	WP_104920204.1	methionine gamma-lyase	-
HVY27_RS12915	2613508..2614806	+	1299	WP_181198552.1	amino acid permease	-
HVY27_RS12920	2614822..2616033	-	1212	WP_181198553.1	sigma 54-interacting transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Type I toxin-antitoxin system, toxin Ldr (1-35)

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 3912.73 Da
• Isoelectric Point: 9.0157

>T165344 WP_000170746.1 NZ_CP057463:c2611626-2611519 [Escherichia fergusonii]
MTLAELGMAFWHDLAAPVITGILASMIVNWLNKRK

Nucleotide

• Length: 108 bp

>T165344 NZ_CP073824:679628-679837 [Staphylococcus epidermidis]
ATGAAATTGAAAAAAGGATTGATAAATGTTTCAGGTATTAAAACAACTGAACAAGCTAAACAGCTCAAAGATCATTTATC
TAAGATGATAGGCATCAATAGTGTGGATATCGATTACCAAATGAATGAGATTCGAGTAGAATTTGACACTCCTGCAAATT
TAAATAACATTGAAAAAGAAATTTACGATTACGGATTTCGTATTTTGTAA

Antitoxin

Nucleotide

• Length: 64 bp

>AT165344 NZ_CP057463:2611675-2611738 [Escherichia fergusonii]
GTCTAGAGTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTT

Structures

Toxin

• AlphaFold DB: A0A826RQE3

Antitoxin