Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yafN-yafO (relBE)/YafO-YafN
Location 1816855..1817549 Replicon chromosome
Accession NZ_CP057463
Organism Escherichia fergusonii strain RHB26-C03

Toxin (Protein)


Gene name yafO Uniprot ID -
Locus tag HVY27_RS09130 Protein ID WP_181199277.1
Coordinates 1816855..1817253 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name yafN Uniprot ID -
Locus tag HVY27_RS09135 Protein ID WP_181199278.1
Coordinates 1817256..1817549 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HVY27_RS09100 1811983..1813440 + 1458 WP_001293009.1 cytosol nonspecific dipeptidase -
HVY27_RS09105 1813449..1813730 + 282 WP_000106440.1 hypothetical protein -
HVY27_RS09110 1813739..1814263 - 525 WP_141095971.1 metal-dependent hydrolase -
HVY27_RS09115 1814325..1814939 - 615 Protein_1788 peptide chain release factor H -
HVY27_RS09120 1814936..1816075 - 1140 WP_181199275.1 RNA ligase RtcB family protein -
HVY27_RS09125 1816393..1816845 - 453 WP_181199276.1 GNAT family N-acetyltransferase -
HVY27_RS09130 1816855..1817253 - 399 WP_181199277.1 type II toxin-antitoxin system mRNA interferase toxin YafO Toxin
HVY27_RS09135 1817256..1817549 - 294 WP_181199278.1 type I toxin-antitoxin system antitoxin YafN Antitoxin
HVY27_RS09140 1817601..1818656 - 1056 WP_181199279.1 DNA polymerase IV -
HVY27_RS09145 1818727..1819513 - 787 Protein_1794 putative lateral flagellar export/assembly protein LafU -
HVY27_RS09150 1819458..1821197 + 1740 WP_181199280.1 flagellar biosynthesis protein FlhA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin YafO

(27-130)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 15530.91 Da        Isoelectric Point: 8.0934

>T165341 WP_181199277.1 NZ_CP057463:c1817253-1816855 [Escherichia fergusonii]
MRVFKTKLIRLQLTDKELDALTADFISYKRDGVLPDIFGRDALYDDSFTWPLIKFERVAHIHLANENNPFPPQLRQFSRT
NDEAHLVYCQGAFDEQAWLLIAILKPEPHKLARDNNQMHKIGKMAEAFRMRF

Download         Length: 399 bp

>T165341 NZ_CP073821:822495-822890 [Staphylococcus epidermidis]
ATGCAAAGCACTAAATATTTAACTGAAAAACAAGTGATTGCCATTAATGTAAAAGCAATACAAGATTTCTCACCAAAAGA
ACAAGTTGGTGTTAAAGTTCCAGAAGTTCTTAATGCTACTATTGAAGGAGTTAAACAATCATTCGGTGGAGTTGAACTAT
ATGAAACAATCGAGAGAAAAGCAGCTTTTATATATAGAAATATAGCTCAAAAGCACGCATTCCATAATGCGAATAAAAGA
ACAGCTTTTACATCTATGGTAATATTTTTGAAGTTAAATAGTATTAATTTTGAATGCACTCAAGATGAAGCGGTTCAGTT
TACTTTAAGAGTAGTAAACGACAAAAATCTTACTCTTGAGGGAATTGAGACATGGATCAAGAGGCATTGTAAATAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11165.69 Da        Isoelectric Point: 5.8944

>AT165341 WP_181199278.1 NZ_CP057463:c1817549-1817256 [Escherichia fergusonii]
MHRILAEKSVNITELRKNPAKYFIDQPVAVLSNNRPAGYLLSASAFEALMDMLAEQEEKKSIKARFRPSAARLEEITRRA
EQYLNDMTDDDFNGFKE

Download         Length: 294 bp

>AT165341 NZ_CP073821:822265-822495 [Staphylococcus epidermidis]
ATGATTACTACAAGAAAACTAAGAAAAGCTGGTAATAGTTCAGTTGTTTCTGTACCGACAGAAGTGATCGCAGCACTCGG
AATATCAAATGGTGATAATCTTAAATTTAATGTAAAAGATAATAAAGTAACCATCGAAAAGGAGGTAAGAGAGGACGAGG
AGTTTTTTAAATTGTTGGATGAAACATTCACTGAGTATAACCAAGCTTTAAAAAGGATGGTTGACTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References