Detailed information of TA system TA165310

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 4149352..4149610
• Replicon: chromosome
• Accession: NZ_CP057458
• Organism: Escherichia fergusonii strain RHB26-C09

Toxin (Protein)

• Gene name: hokA
• Uniprot ID: -
• Locus tag: HVY30_RS20015
• Protein ID: WP_001135723.1
• Coordinates: 4149352..4149504 (-)
• Length: 51 a.a.

Antitoxin (RNA)

Gene name	sokA
Locus tag	-
Coordinates	4149555..4149610 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HVY30_RS19990	4145216..4145926	-	711	WP_000190514.1	DUF3053 domain-containing protein	-
HVY30_RS19995	4146364..4147734	+	1371	WP_000184983.1	MFS transporter	-
HVY30_RS20000	4147984..4148274	+	291	WP_000455800.1	HTH-type transcriptional regulator	-
HVY30_RS20005	4148556..4148768	+	213	WP_000014594.1	RNA chaperone/antiterminator CspA	-
HVY30_RS20010	4148822..4149193	-	372	WP_001037804.1	membrane protein insertion efficiency factor YidD	-
HVY30_RS20015	4149352..4149504	-	153	WP_001135723.1	type I toxin-antitoxin system toxin HokA	Toxin
-	4149555..4149610	+	56	-	-	Antitoxin
HVY30_RS20020	4149827..4151896	-	2070	WP_001291786.1	glycine--tRNA ligase subunit beta	-
HVY30_RS20025	4151906..4152817	-	912	WP_001168544.1	glycine--tRNA ligase subunit alpha	-
HVY30_RS20030	4152913..4153212	-	300	WP_024256552.1	YsaB family lipoprotein	-
HVY30_RS20035	4153384..4154379	+	996	WP_015953832.1	acyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-46)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5899.14 Da
• Isoelectric Point: 6.9160

>T165310 WP_001135723.1 NZ_CP057458:c4149504-4149352 [Escherichia fergusonii]
MPQKYGLLSLIVICFTLLFFTWMIRDSLCELHIKQESYELAAFLACKLKE

Nucleotide

• Length: 153 bp

>T165310 NZ_CP073797:10430465-10430830 [Dactylosporangium matsuzakiense]
GTGACCACACCGGAGTGGGGCATCTACGTTGTCGACGAAGTCCGCGCCTGGATCTACTCGTTGGAACCAACAGCCAAGGC
CAGGGTCGTGCTTGCGATCGATGCCCTTGCGGAGAACGGGCCTGCTCTCGGGCGCCCCCTCGTCGACACCATCACACATT
CGTCGCTCGCCAACCTGAAGGAGCTACGGCCCGGGACGATGCGCATCCTGTTCGTCTTCGACCCTTGGCGATCCAGCATC
TTGCTCGTGGCCGGCGACAAGGCGGGACAATGGGAGGCTTGGTACCGGGAGGCGTTACCGCTCGCGGAACAGCGATACGA
GGTCTACCTGAAGGAACGGGCAAAGGAAGAGGGGGACCAGCGATGA

Antitoxin

Nucleotide

• Length: 56 bp

>AT165310 NZ_CP057458:4149555-4149610 [Escherichia fergusonii]
GTTGAAGCATAGAGGCAGCCTCACTTTGATTTATAGTCAGGTGGGGCTTTTCTCTG

Structures

Antitoxin