Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yafN-yafO (relBE)/YafO-YafN
Location 3334155..3334849 Replicon chromosome
Accession NZ_CP057458
Organism Escherichia fergusonii strain RHB26-C09

Toxin (Protein)


Gene name yafO Uniprot ID -
Locus tag HVY30_RS16120 Protein ID WP_181199277.1
Coordinates 3334155..3334553 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name yafN Uniprot ID -
Locus tag HVY30_RS16125 Protein ID WP_046080635.1
Coordinates 3334556..3334849 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HVY30_RS16090 3329410..3330867 + 1458 WP_001293012.1 cytosol nonspecific dipeptidase -
HVY30_RS16095 3330876..3331157 + 282 WP_000106440.1 hypothetical protein -
HVY30_RS16100 3331166..3331690 - 525 WP_181670058.1 metal-dependent hydrolase -
HVY30_RS16105 3331752..3332366 - 615 WP_000602127.1 peptide chain release factor H -
HVY30_RS16110 3332363..3333502 - 1140 WP_181671618.1 RNA ligase RtcB family protein -
HVY30_RS16115 3333693..3334145 - 453 WP_001059848.1 GNAT family N-acetyltransferase -
HVY30_RS16120 3334155..3334553 - 399 WP_181199277.1 type II toxin-antitoxin system mRNA interferase toxin YafO Toxin
HVY30_RS16125 3334556..3334849 - 294 WP_046080635.1 type I toxin-antitoxin system antitoxin YafN Antitoxin
HVY30_RS16130 3334901..3335956 - 1056 WP_104917900.1 DNA polymerase IV -
HVY30_RS16135 3336027..3336812 - 786 WP_162754239.1 putative lateral flagellar export/assembly protein LafU -
HVY30_RS16140 3336757..3338496 + 1740 WP_181665643.1 flagellar biosynthesis protein FlhA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin YafO

(27-130)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 15530.91 Da        Isoelectric Point: 8.0934

>T165300 WP_181199277.1 NZ_CP057458:c3334553-3334155 [Escherichia fergusonii]
MRVFKTKLIRLQLTDKELDALTADFISYKRDGVLPDIFGRDALYDDSFTWPLIKFERVAHIHLANENNPFPPQLRQFSRT
NDEAHLVYCQGAFDEQAWLLIAILKPEPHKLARDNNQMHKIGKMAEAFRMRF

Download         Length: 399 bp

>T165300 NZ_CP073791:5276403-5276786 [Klebsiella pneumoniae]
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCGTCGCGAAGCCAAACAGGCGCT
GGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATTACCTGGATGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGCACGCGAATGGCGCTGAGCACCTTTAATATCATTAACATCTCACAGGATATTGCAGAGCGAAGCGTTGCGCTG
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCATCATTCTGGCGACGGCGCAACTCCATCGTCTGGAACTAATTACGCG
GAATACGAAGGATTTTGCCGGTATTCCTGGCGTAGTCACGCCGTACGAAATCCACCCTGAATAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11223.72 Da        Isoelectric Point: 5.2170

>AT165300 WP_046080635.1 NZ_CP057458:c3334849-3334556 [Escherichia fergusonii]
MHRILAEKSVNITELRKNPAKYFIDQPVAVLSNNRPAGYLLSASAFEALMDMLAEQEEKKSIKARFRPSAARLEEITRRA
EQYLNDMTDDDFNDFKE

Download         Length: 294 bp

>AT165300 NZ_CP073791:5276161-5276403 [Klebsiella pneumoniae]
ATGATGGCTGAAAGGGATATGGGCAGAATTCTTCTCGATTTATCAGACGATGTCATTCAACGTCTCGATGACCTCAAAGT
GCAGCGTAACATTCCGCGAGCGGAACTGTTACGTGAAGCGGTTGAACAATATCTGGAGAAACAAGATCGAGCTAAAGATA
CCATCTCCAGTGCGCTGGGTCTGTGGCAAGACTGCGAAGAAGACGGCATGGAATATCAACGTCAGCTACGCAAGGAGTGG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References