Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 2061305..2061867 Replicon chromosome
Accession NZ_CP057458
Organism Escherichia fergusonii strain RHB26-C09

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag HVY30_RS09855 Protein ID WP_181669796.1
Coordinates 2061589..2061867 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID S1PAQ1
Locus tag HVY30_RS09850 Protein ID WP_000781370.1
Coordinates 2061305..2061589 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HVY30_RS09835 2056664..2059711 + 3048 WP_181671733.1 formate dehydrogenase-N subunit alpha -
HVY30_RS09840 2059724..2060608 + 885 WP_148048370.1 formate dehydrogenase N subunit beta -
HVY30_RS09845 2060601..2061254 + 654 WP_000045648.1 formate dehydrogenase-N subunit gamma -
HVY30_RS09850 2061305..2061589 - 285 WP_000781370.1 HigA family addiction module antidote protein Antitoxin
HVY30_RS09855 2061589..2061867 - 279 WP_181669796.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HVY30_RS09860 2062053..2063063 - 1011 WP_000642407.1 alcohol dehydrogenase AdhP -
HVY30_RS09865 2063198..2064895 - 1698 WP_000433464.1 malate dehydrogenase -
HVY30_RS09870 2065052..2065189 - 138 WP_000841554.1 stationary-phase-induced ribosome-associated protein -
HVY30_RS09875 2065291..2065506 - 216 WP_000495766.1 biofilm-dependent modulation protein -
HVY30_RS09880 2065850..2066281 + 432 WP_000152305.1 peroxiredoxin OsmC -
HVY30_RS09885 2066342..2066482 + 141 WP_109043809.1 omptin family outer membrane protease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-88)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10565.16 Da        Isoelectric Point: 7.3562

>T165297 WP_181669796.1 NZ_CP057458:c2061867-2061589 [Escherichia fergusonii]
MIMNFRHKGLRDLFLLGKTSGVIPTQIKRLRHRLAVIDATSCLADLDMPGYRLHPLSGDRDGIWAISVSGNWRITFEFVN
GDAYILDYEDYH

Download         Length: 279 bp

>T165297 NZ_CP073791:c4462085-4461600 [Klebsiella pneumoniae]
ATGATCTCGGCACCAGAACCGCTTCATGCCGGGCATATTCTTACCCCGTTTTGCTGCGGTATAGATTCCATGGATCACTG
GCTGAAACAGCGGGCGATGAAAAATCAGGTTACTGGCGCATCCCGCACCTTTGTCTGCTGCGACGACGCGAAGGTGATGG
CTTACTACTCACTGGCTTCCAGCGCTGTGACGACAAATACTGCGCCGGGTCGTTTTCGCCGCAATATGCCTGCCCCGATC
CCGGTTGTGGTACTGGGTCGTCTGGCGGTGGATAAATCACTACATGGGAAAGGTGTCGGGCGGGCCCTGGTACGTGATGC
CGGGCTGCGTGTGATTCAGGTGGCGGAGACTATCGGCATTCGCGGGATGCTGGTTCACGCCCTGTCGGATGAAGCACGGG
ATTTTTACCTGCGGGTGGGGTTTGAGCCGTCGCCGATGGATCCGATGATGTTGATGGTGACGTTGAGGGATTTGGTTAAT
GCCTGA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10401.08 Da        Isoelectric Point: 8.8567

>AT165297 WP_000781370.1 NZ_CP057458:c2061589-2061305 [Escherichia fergusonii]
MKMANHPRPGDIIQESLDELNVSLREFARAMEIAPSTASRLLTGKAALTPEMAIKLSVVIGSSPQMWLNLQNAWSLAEAE
KTVDVSRLRRLVTQ

Download         Length: 285 bp

>AT165297 NZ_CP073791:c4462375-4462082 [Klebsiella pneumoniae]
ATGCCAGCCGCAAACAGCATGTCCATAAAACGCGAAACGTTAAATCTGCGCATTAAACCTGCCGAACGCGATCTTATTGA
TCGGGCGGCGAAAGCCAGAGGGAAAAACCGCACAGACTTTGTGCTGGAGGCCGCCCGCGCTGCCGCTGAGGAAGCGCTGA
TTGAGCAACGCATCATTATGGCCGATCCGCAGGCTTATCAGGAATTTCTCGCTCGTCTGGATCAGGCTCCTGCACCTAAT
GCCGCACTGCGTAAAACTATGCAGACCCCTGCGCCGTGGGAACAGGAAGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 2ICT
PDB 2ICP
AlphaFold DB A0A829CUG6

References