Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 524301..524863 Replicon chromosome
Accession NZ_CP057357
Organism Escherichia fergusonii strain RHB28-C21

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag HVY57_RS02685 Protein ID WP_104919749.1
Coordinates 524585..524863 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID S1PAQ1
Locus tag HVY57_RS02680 Protein ID WP_000781370.1
Coordinates 524301..524585 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HVY57_RS02665 519660..522707 + 3048 WP_015953395.1 formate dehydrogenase-N subunit alpha -
HVY57_RS02670 522720..523604 + 885 WP_104918434.1 formate dehydrogenase N subunit beta -
HVY57_RS02675 523597..524250 + 654 WP_000045648.1 formate dehydrogenase-N subunit gamma -
HVY57_RS02680 524301..524585 - 285 WP_000781370.1 HigA family addiction module antidote protein Antitoxin
HVY57_RS02685 524585..524863 - 279 WP_104919749.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HVY57_RS02690 525049..526059 - 1011 WP_000642415.1 alcohol dehydrogenase AdhP -
HVY57_RS02695 526194..527891 - 1698 WP_000433464.1 malate dehydrogenase -
HVY57_RS02700 528048..528185 - 138 WP_000841554.1 stationary-phase-induced ribosome-associated protein -
HVY57_RS02705 528287..528502 - 216 WP_000495766.1 biofilm-dependent modulation protein -
HVY57_RS02710 528845..529276 + 432 WP_181673040.1 peroxiredoxin OsmC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-88)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10521.10 Da        Isoelectric Point: 7.3562

>T165263 WP_104919749.1 NZ_CP057357:c524863-524585 [Escherichia fergusonii]
MIMNFRHKGLRDLFLLGKTSGVIPTQVKRLRHRLAVIDAASCLADLDMPGYRLHPLSGDRDGIWAISVSGNWRITFEFVN
GDAYILDYEDYH

Download         Length: 279 bp

>T165263 NZ_CP073783:309043-309411 [Klebsiella pneumoniae]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCGGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACCCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCAGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCAGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGTTTGCGTGGATGA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10401.08 Da        Isoelectric Point: 8.8567

>AT165263 WP_000781370.1 NZ_CP057357:c524585-524301 [Escherichia fergusonii]
MKMANHPRPGDIIQESLDELNVSLREFARAMEIAPSTASRLLTGKAALTPEMAIKLSVVIGSSPQMWLNLQNAWSLAEAE
KTVDVSRLRRLVTQ

Download         Length: 285 bp

>AT165263 NZ_CP073783:308825-309046 [Klebsiella pneumoniae]
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGGCGGCCAGAATGGATG
ATGAGTTCGCGGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 2ICT
PDB 2ICP
AlphaFold DB A0A829CUG6

References