Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 298880..299546 Replicon chromosome
Accession NZ_CP057353
Organism Citrobacter freundii strain RHB29-C07

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag HVY60_RS01400 Protein ID WP_117342464.1
Coordinates 299229..299546 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A4U6IRD5
Locus tag HVY60_RS01395 Protein ID WP_003837894.1
Coordinates 298880..299176 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HVY60_RS01380 296056..296529 - 474 WP_005121627.1 transcription elongation factor GreB -
HVY60_RS01385 296756..297475 + 720 WP_001157751.1 two-component system response regulator OmpR -
HVY60_RS01390 297472..298824 + 1353 WP_096759268.1 two-component system sensor histidine kinase EnvZ -
HVY60_RS01395 298880..299176 - 297 WP_003837894.1 helix-turn-helix domain-containing protein Antitoxin
HVY60_RS01400 299229..299546 - 318 WP_117342464.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HVY60_RS01405 299670..301292 - 1623 WP_115257300.1 phosphoenolpyruvate carboxykinase (ATP) -
HVY60_RS01410 301671..303389 + 1719 WP_181695206.1 DUF4153 domain-containing protein -
HVY60_RS01415 303440..304318 - 879 WP_096759272.1 Hsp33 family molecular chaperone HslO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(39-75)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12226.13 Da        Isoelectric Point: 9.8310

>T165240 WP_117342464.1 NZ_CP057353:c299546-299229 [Citrobacter freundii]
MFTFIELQGFSKRRPLLLPDDEFRAFQEALIENPEAGDTIAGTGGFRKIRWSRSGMGKRSGIRVIYYNVTRKGRIYLALL
YPKNEQDDLTEEQKRVLMHLSDMLI

Download         Length: 318 bp

>T165240 NZ_CP073771:c2720070-2719967 [Enterobacter hormaechei]
GGCAAGGCGATTGAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11157.93 Da        Isoelectric Point: 7.2050

>AT165240 WP_003837894.1 NZ_CP057353:c299176-298880 [Citrobacter freundii]
MKDELFADLLASAEEMVRIEKGEETPKPEHVHTFSEIDVKAIREATGLRQQDFAIAVGVSYDLVKSWETKRRQPTGAPRK
LLLLIQKNPFIINQLKAI

Download         Length: 297 bp

>AT165240 NZ_CP073771:2719962-2720163 [Enterobacter hormaechei]
CAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTT
GGCATTAATGCAGGCTCAATCGCCTTGCCCTTTAAGAATAGATGACGACGTCAGGTTTTCCAGTCCACAGTAAAAGTGGT
CTGAAAAAAAGCGTCAGAACATCACTAAATGTGAAAAACCGC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A4U6IRD5

References