Detailed information of TA system TA165193

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 3526271..3526529
• Replicon: chromosome
• Accession: NZ_CP057311
• Organism: Escherichia fergusonii strain RHB30-C07

Toxin (Protein)

• Gene name: hokC
• Uniprot ID: -
• Locus tag: HVY75_RS17060
• Protein ID: WP_000935262.1
• Coordinates: 3526271..3526480 (-)
• Length: 70 a.a.

Antitoxin (RNA)

Gene name	sokC
Locus tag	-
Coordinates	3526472..3526529 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HVY75_RS17040	3521337..3521924	+	588	WP_002431696.1	molybdopterin adenylyltransferase	-
HVY75_RS17045	3521958..3522524	-	567	WP_000528529.1	acetate uptake transporter	-
HVY75_RS17050	3523032..3524948	+	1917	WP_000516135.1	molecular chaperone DnaK	-
HVY75_RS17055	3525037..3526167	+	1131	WP_001118464.1	molecular chaperone DnaJ	-
HVY75_RS17060	3526271..3526480	-	210	WP_000935262.1	type I toxin-antitoxin system Hok family toxin	Toxin
-	3526472..3526529	+	58	-	-	Antitoxin
HVY75_RS17065	3526964..3528130	+	1167	WP_000681374.1	Na+/H+ antiporter NhaA	-
HVY75_RS17070	3528198..3529097	+	900	WP_000019049.1	transcriptional activator NhaR	-
HVY75_RS17075	3529193..3529456	-	264	WP_001274021.1	30S ribosomal protein S20	-
HVY75_RS17080	3529559..3529777	+	219	WP_181203115.1	DUF2575 domain-containing protein	-
HVY75_RS17085	3529785..3530726	+	942	WP_000767329.1	bifunctional riboflavin kinase/FAD synthetase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (25-66)

Sequences

Toxin

Protein

• Length: 70 a.a.
• Molecular weight: 7742.28 Da
• Isoelectric Point: 9.3680

>T165193 WP_000935262.1 NZ_CP057311:c3526480-3526271 [Escherichia fergusonii]
MLNTCRVPLTDRKVKEKRAMKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Nucleotide

• Length: 210 bp

>T165193 NZ_CP073754:c1554664-1554263 [Methylomonas paludis]
ATGCTGGATACCAATACGGTCAGCTATATTATCAAAAACCATCCCCCTGAGATTCGTAAGCGGCTGGCATCCCTGCCAAT
GGACAGCATTACCATATCCGCAGTCACACAAGGTGAACTTTTATATGGCTTAGCCCGAAAGGGATATCCTGCCACTCTGG
CAAAACTGATCCGGGAATTTCTATTTCGGGTTGAAACGTTACCTTGGGACGAGCAAGCCGCCAGCGTTTACGGCGATTTA
CGCGCTTCTTGCATGACGGTTGGCATTTCACTTGGGGCACTCGACATGATGATCGCCGCGCATGCAATAGCTGCCAATAC
CATACTTGTCAGCCATGATAAAGCATTTAGCCTGGTTCCCGATGGCGTTTTGACTATCGAAGATTGGATGCATGGCTTCT
GA

Antitoxin

Nucleotide

• Length: 58 bp

>AT165193 NZ_CP057311:3526472-3526529 [Escherichia fergusonii]
GTTCAGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Structures

Antitoxin