Detailed information of TA system TA165189

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 2610820..2611078
• Replicon: chromosome
• Accession: NZ_CP057311
• Organism: Escherichia fergusonii strain RHB30-C07

Toxin (Protein)

• Gene name: hokA
• Uniprot ID: -
• Locus tag: HVY75_RS12695
• Protein ID: WP_181202950.1
• Coordinates: 2610820..2610972 (-)
• Length: 51 a.a.

Antitoxin (RNA)

Gene name	sokA
Locus tag	-
Coordinates	2611023..2611078 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HVY75_RS12670	2606684..2607394	-	711	WP_000190514.1	DUF3053 domain-containing protein	-
HVY75_RS12675	2607832..2609202	+	1371	WP_000184983.1	MFS transporter	-
HVY75_RS12680	2609452..2609742	+	291	WP_000455800.1	HTH-type transcriptional regulator	-
HVY75_RS12685	2610024..2610236	+	213	WP_000014594.1	RNA chaperone/antiterminator CspA	-
HVY75_RS12690	2610290..2610661	-	372	WP_001037803.1	membrane protein insertion efficiency factor YidD	-
HVY75_RS12695	2610820..2610972	-	153	WP_181202950.1	type I toxin-antitoxin system toxin HokA	Toxin
-	2611023..2611078	+	56	-	-	Antitoxin
HVY75_RS12700	2611273..2611632	-	360	WP_141095883.1	hypothetical protein	-
HVY75_RS12705	2611701..2613770	-	2070	WP_001291786.1	glycine--tRNA ligase subunit beta	-
HVY75_RS12710	2613780..2614691	-	912	WP_181202951.1	glycine--tRNA ligase subunit alpha	-
HVY75_RS12715	2614787..2615086	-	300	WP_024256552.1	YsaB family lipoprotein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-46)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5926.17 Da
• Isoelectric Point: 6.9160

>T165189 WP_181202950.1 NZ_CP057311:c2610972-2610820 [Escherichia fergusonii]
MPQKYGLLSLIVICFTLLFFTWMIRDSLCELHIKQENYELAAFLACKLKE

Nucleotide

• Length: 153 bp

>T165189 NZ_CP073754:494390-494680 [Methylomonas paludis]
ATGCGCAAAATCCATACTCAGGCACTCGCAAAACAGGATATAAAAAATATCTGGCTTTACTCTTTTAACAAATGGGGAGA
GGAGCAGGCGGATTTTTATTTTGATGAATTAAATGATGCTTTCGCTTTAATTGCTGAAAATCCGGAATTGGGTTTTGCCT
GTGATTACATTCGGGAAGGGTACAGACAATTCCACATCAATCGTCATTTAATTTTTTATTGTGTTTCAGCTACCAAGATT
CATATTATACGGGTACTACACGACAGTATGAATTACATCGTGCATTTATAA

Antitoxin

Nucleotide

• Length: 56 bp

>AT165189 NZ_CP057311:2611023-2611078 [Escherichia fergusonii]
GTTGAAGCATAGAGGCAGCCTCACTTTGATTTATAGTCAGGTGGGGCTTTTCTCTG

Structures

Antitoxin