Detailed information of TA system TA165170

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 3809347..3809593
• Replicon: chromosome
• Accession: NZ_CP057266
• Organism: Escherichia fergusonii strain RHB31-C13

Toxin (Protein)

• Gene name: hokX
• Uniprot ID: S1PD89
• Locus tag: HVY87_RS18420
• Protein ID: WP_000956458.1
• Coordinates: 3809441..3809593 (+)
• Length: 51 a.a.

Antitoxin (RNA)

Gene name	sokX
Locus tag	-
Coordinates	3809347..3809399 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HVY87_RS18405	3804855..3806654	+	1800	WP_000211943.1	NADPH-dependent assimilatory sulfite reductase flavoprotein subunit	-
HVY87_RS18410	3806654..3808366	+	1713	WP_046083135.1	assimilatory sulfite reductase (NADPH) hemoprotein subunit	-
HVY87_RS18415	3808440..3809174	+	735	WP_046083134.1	phosphoadenosine phosphosulfate reductase	-
-	3809347..3809399	-	53	-	-	Antitoxin
HVY87_RS18420	3809441..3809593	+	153	WP_000956458.1	type I toxin-antitoxin system Hok family toxin	Toxin
HVY87_RS18425	3809829..3812486	+	2658	WP_181672359.1	CRISPR-associated helicase Cas3'	-
HVY87_RS18430	3812584..3814146	+	1563	WP_046083149.1	type I-E CRISPR-associated protein Cse1/CasA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	3800390..3809593	9203

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (5-46)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5558.77 Da
• Isoelectric Point: 7.6757

>T165170 WP_000956458.1 NZ_CP057266:3809441-3809593 [Escherichia fergusonii]
MLTKYALVAIIVLCCTVLGFTLMVGDSLCELSIRERGMEFKAVLAYESKK

Nucleotide

• Length: 153 bp

>T165170 NZ_CP073721:7035723-7035983 [Dactylosporangium roseum]
GTGAAGCTCAGTTGGACTGACCTCGCCTGGGACGACTATCTGTACTGGCAGACGCAGGACCGCAAGACGCTCAGGCGCAT
CAACGCCTTGATCGCAGACATCAAGCGCGATCCAGACGGACCTGGCATCGGTAAACCCGAGCTCCTGAGGAACAATCTGG
CCGGCCTACGCTCCCGCCGAATCGACGACGAGCACCGCCTCGTTTACGCCGTCACACCAGACGAAGTAACAATCATCTCC
TGCCGCTACCGCTACCAGTGA

Antitoxin

Nucleotide

• Length: 53 bp

>AT165170 NZ_CP057266:c3809399-3809347 [Escherichia fergusonii]
TTAGGTTCGAACGCTGGCCTCAGGTTGATAGAAATATCGCCTGGGGCTTTTGT

Structures

Toxin

• AlphaFold DB: A0A4P7TJ83

Antitoxin