Detailed information of TA system TA165167

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 3506266..3506524
• Replicon: chromosome
• Accession: NZ_CP057266
• Organism: Escherichia fergusonii strain RHB31-C13

Toxin (Protein)

• Gene name: hokC
• Uniprot ID: -
• Locus tag: HVY87_RS17040
• Protein ID: WP_000935262.1
• Coordinates: 3506266..3506475 (-)
• Length: 70 a.a.

Antitoxin (RNA)

Gene name	sokC
Locus tag	-
Coordinates	3506467..3506524 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HVY87_RS17020	3501332..3501919	+	588	WP_046083027.1	molybdopterin adenylyltransferase	-
HVY87_RS17025	3501953..3502519	-	567	WP_000528529.1	acetate uptake transporter	-
HVY87_RS17030	3503027..3504943	+	1917	WP_000516135.1	molecular chaperone DnaK	-
HVY87_RS17035	3505032..3506162	+	1131	WP_001118464.1	molecular chaperone DnaJ	-
HVY87_RS17040	3506266..3506475	-	210	WP_000935262.1	type I toxin-antitoxin system Hok family toxin	Toxin
-	3506467..3506524	+	58	-	-	Antitoxin
HVY87_RS17045	3506959..3508125	+	1167	WP_046076806.1	Na+/H+ antiporter NhaA	-
HVY87_RS17050	3508193..3509092	+	900	WP_000019049.1	transcriptional activator NhaR	-
HVY87_RS17055	3509188..3509451	-	264	WP_001274021.1	30S ribosomal protein S20	-
HVY87_RS17060	3509554..3509772	+	219	WP_012599853.1	DUF2575 family protein	-
HVY87_RS17065	3509780..3510721	+	942	WP_046081994.1	bifunctional riboflavin kinase/FAD synthetase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (25-66)

Sequences

Toxin

Protein

• Length: 70 a.a.
• Molecular weight: 7742.28 Da
• Isoelectric Point: 9.3680

>T165167 WP_000935262.1 NZ_CP057266:c3506475-3506266 [Escherichia fergusonii]
MLNTCRVPLTDRKVKEKRAMKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Nucleotide

• Length: 210 bp

>T165167 NZ_CP073720:10311222-10311587 [Dactylosporangium fulvum]
GTGACCACATCGGAGTGGGACATCTATGTGGTGAACGAGGTTCGCGAGTGGATCCGGTCACTGGACCCTGCTACGAAGAG
GCGGGTCGTCGAAGCGATCGACGTGCTCGCCGAACGGGGCCCTGGCCTCGGCCGACCGCTCGTCGACAGCATCGCGCATT
CCTCGATCGTCAACCTGAAGGAGTTGCGTCCGGGAACAGTACGCATCCTGTTCGTCTTCGACCCTTGGCGGTCCAGCATC
CTGCTCGTCGGAGGCGACAAGGCAGGTAGGTGGGACGCTTGGTACCTGGAAGCCATCCCGCTCGCGGAGCAGCGCTACGA
GACTTACCTGAAGGAACGAGCACAGGAGGAAGGGGGTCGGTCGTGA

Antitoxin

Nucleotide

• Length: 58 bp

>AT165167 NZ_CP057266:3506467-3506524 [Escherichia fergusonii]
GTTCAGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Structures

Antitoxin