Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 1037200..1037702 Replicon chromosome
Accession NZ_CP057266
Organism Escherichia fergusonii strain RHB31-C13

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag HVY87_RS05090 Protein ID WP_046083399.1
Coordinates 1037200..1037454 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag HVY87_RS05095 Protein ID WP_001259255.1
Coordinates 1037451..1037702 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HVY87_RS05060 1032215..1032442 - 228 WP_000985273.1 sulfurtransferase TusA family protein -
HVY87_RS05065 1032456..1033514 - 1059 WP_046080827.1 transport protein YeeE -
HVY87_RS05070 1033694..1035052 - 1359 WP_000019201.1 putrescine/proton symporter PlaP -
HVY87_RS05075 1035042..1035104 - 63 WP_010723108.1 membrane protein YoeI -
HVY87_RS05080 1035318..1036247 - 930 WP_000803361.1 LysR family transcriptional regulator -
HVY87_RS05085 1036293..1037117 - 825 WP_000754726.1 SDR family oxidoreductase -
HVY87_RS05090 1037200..1037454 - 255 WP_046083399.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
HVY87_RS05095 1037451..1037702 - 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
HVY87_RS05100 1037986..1038036 + 51 WP_001364200.1 his operon leader peptide -
HVY87_RS05105 1038182..1039081 + 900 WP_000131779.1 ATP phosphoribosyltransferase -
HVY87_RS05110 1039087..1040391 + 1305 WP_046083400.1 histidinol dehydrogenase -
HVY87_RS05115 1040388..1041458 + 1071 WP_046083401.1 histidinol-phosphate transaminase -
HVY87_RS05120 1041458..1042525 + 1068 WP_046083402.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10201.62 Da        Isoelectric Point: 8.0353

>T165155 WP_046083399.1 NZ_CP057266:c1037454-1037200 [Escherichia fergusonii]
VKLIWSEESWDDYMYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

>T165155 NZ_CP073719:1083057-1083392 [Escherichia coli]
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCCGG
ACATCGTCCGGCTGTTGTCCTGAGTCCGTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTGTACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAAGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACGGTTGTCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTACTGATTGGGTAG

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT165155 WP_001259255.1 NZ_CP057266:c1037702-1037451 [Escherichia fergusonii]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp

>AT165155 NZ_CP073719:1082809-1083057 [Escherichia coli]
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGAGAGCCGAAAGATAAGGAA
GTCTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 2A6Q
AlphaFold DB A0A7U9LNR0

References