Detailed information of TA system TA165130

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 2538278..2538536
• Replicon: chromosome
• Accession: NZ_CP057256
• Organism: Escherichia fergusonii strain RHB31-C17

Toxin (Protein)

• Gene name: hokA
• Uniprot ID: -
• Locus tag: HVY91_RS12330
• Protein ID: WP_001135723.1
• Coordinates: 2538278..2538430 (-)
• Length: 51 a.a.

Antitoxin (RNA)

Gene name	sokA
Locus tag	-
Coordinates	2538481..2538536 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HVY91_RS12305	2534142..2534852	-	711	WP_000190514.1	DUF3053 domain-containing protein	-
HVY91_RS12310	2535290..2536660	+	1371	WP_000184983.1	MFS transporter	-
HVY91_RS12315	2536910..2537200	+	291	WP_000455800.1	HTH-type transcriptional regulator	-
HVY91_RS12320	2537482..2537694	+	213	WP_000014594.1	RNA chaperone/antiterminator CspA	-
HVY91_RS12325	2537748..2538119	-	372	WP_181669305.1	membrane protein insertion efficiency factor YidD	-
HVY91_RS12330	2538278..2538430	-	153	WP_001135723.1	type I toxin-antitoxin system toxin HokA	Toxin
-	2538481..2538536	+	56	-	-	Antitoxin
HVY91_RS12335	2538753..2540822	-	2070	WP_001291786.1	glycine--tRNA ligase subunit beta	-
HVY91_RS12340	2540832..2541743	-	912	WP_001168544.1	glycine--tRNA ligase subunit alpha	-
HVY91_RS12345	2541839..2542138	-	300	WP_024256552.1	YsaB family lipoprotein	-
HVY91_RS12350	2542310..2543305	+	996	WP_015953832.1	acyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-46)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5899.14 Da
• Isoelectric Point: 6.9160

>T165130 WP_001135723.1 NZ_CP057256:c2538430-2538278 [Escherichia fergusonii]
MPQKYGLLSLIVICFTLLFFTWMIRDSLCELHIKQESYELAAFLACKLKE

Nucleotide

• Length: 153 bp

>T165130 NZ_CP073718:263008-263283 [Escherichia coli]
ATGAGAACCAAGGTACAGGCTTTACGGAAGAAACAAAAAAATACATTGGATCAAATATTTAAAACTCCTGTTCCTCAAGG
GATTAAGTGGTCTGATATAGAGTCACTGGTTAAAGCATTAGGCGGAGAAATTAAGGAAGGAAGAGGTTCGCGTTGTAAGT
TCATACTAAATATGAGCGTTGCGTGTTTCCATCGGCCTCATCCGTCGCCAGATACCGATAAAGGCGCTGTAGAAAGCGTG
CGTGACTGGTTACTAAGTATAGGGGTAAAACCATGA

Antitoxin

Nucleotide

• Length: 56 bp

>AT165130 NZ_CP057256:2538481-2538536 [Escherichia fergusonii]
GTTGAAGCATAGAGGCAGCCTCACTTTGATTTATAGTCAGGTGGGGCTTTTCTCTG

Structures

Antitoxin