Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yafN-yafO (relBE)/YafO-YafN
Location 1742376..1743070 Replicon chromosome
Accession NZ_CP057256
Organism Escherichia fergusonii strain RHB31-C17

Toxin (Protein)


Gene name yafO Uniprot ID -
Locus tag HVY91_RS08545 Protein ID WP_181199277.1
Coordinates 1742376..1742774 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name yafN Uniprot ID -
Locus tag HVY91_RS08550 Protein ID WP_046080635.1
Coordinates 1742777..1743070 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HVY91_RS08515 1737631..1739088 + 1458 WP_001293012.1 cytosol nonspecific dipeptidase -
HVY91_RS08520 1739097..1739378 + 282 WP_000106440.1 hypothetical protein -
HVY91_RS08525 1739387..1739911 - 525 WP_181670058.1 metal-dependent hydrolase -
HVY91_RS08530 1739973..1740587 - 615 WP_000602127.1 peptide chain release factor H -
HVY91_RS08535 1740584..1741723 - 1140 Protein_1672 RNA ligase RtcB family protein -
HVY91_RS08540 1741914..1742366 - 453 WP_001059848.1 GNAT family N-acetyltransferase -
HVY91_RS08545 1742376..1742774 - 399 WP_181199277.1 type II toxin-antitoxin system mRNA interferase toxin YafO Toxin
HVY91_RS08550 1742777..1743070 - 294 WP_046080635.1 type I toxin-antitoxin system antitoxin YafN Antitoxin
HVY91_RS08555 1743122..1744177 - 1056 WP_104917900.1 DNA polymerase IV -
HVY91_RS08560 1744248..1745033 - 786 WP_162754239.1 putative lateral flagellar export/assembly protein LafU -
HVY91_RS08565 1744978..1746717 + 1740 WP_181665643.1 flagellar biosynthesis protein FlhA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1642705..1755189 112484


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin YafO

(27-130)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 15530.91 Da        Isoelectric Point: 8.0934

>T165120 WP_181199277.1 NZ_CP057256:c1742774-1742376 [Escherichia fergusonii]
MRVFKTKLIRLQLTDKELDALTADFISYKRDGVLPDIFGRDALYDDSFTWPLIKFERVAHIHLANENNPFPPQLRQFSRT
NDEAHLVYCQGAFDEQAWLLIAILKPEPHKLARDNNQMHKIGKMAEAFRMRF

Download         Length: 399 bp

>T165120 NZ_CP073715:1990981-1991084 [Salmonella enterica subsp. enterica serovar Bovismorbificans]
GGCAAGGCGATTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11223.72 Da        Isoelectric Point: 5.2170

>AT165120 WP_046080635.1 NZ_CP057256:c1743070-1742777 [Escherichia fergusonii]
MHRILAEKSVNITELRKNPAKYFIDQPVAVLSNNRPAGYLLSASAFEALMDMLAEQEEKKSIKARFRPSAARLEEITRRA
EQYLNDMTDDDFNDFKE

Download         Length: 294 bp

>AT165120 NZ_CP073715:c1991086-1990943 [Salmonella enterica subsp. enterica serovar Bovismorbificans]
ATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGC
ATTAATGCAGGCTAAATCGCCTTGCCCTTTAAGAATAGATGACGACGCCAGGTTTTCCAGTTTG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References