Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 1036397..1036899 Replicon chromosome
Accession NZ_CP057256
Organism Escherichia fergusonii strain RHB31-C17

Toxin (Protein)


Gene name yoeB Uniprot ID U9YDH0
Locus tag HVY91_RS05080 Protein ID WP_000767829.1
Coordinates 1036397..1036651 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag HVY91_RS05085 Protein ID WP_001259255.1
Coordinates 1036648..1036899 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HVY91_RS05050 1031413..1031640 - 228 WP_000985273.1 sulfurtransferase TusA family protein -
HVY91_RS05055 1031654..1032712 - 1059 WP_181669901.1 transport protein YeeE -
HVY91_RS05060 1032891..1034249 - 1359 WP_000019201.1 putrescine/proton symporter PlaP -
HVY91_RS05065 1034239..1034301 - 63 WP_010723108.1 membrane protein YoeI -
HVY91_RS05070 1034515..1035444 - 930 WP_000803361.1 LysR family transcriptional regulator -
HVY91_RS05075 1035490..1036314 - 825 WP_000754745.1 SDR family oxidoreductase -
HVY91_RS05080 1036397..1036651 - 255 WP_000767829.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
HVY91_RS05085 1036648..1036899 - 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
HVY91_RS05090 1037183..1037233 + 51 WP_001364200.1 his operon leader peptide -
HVY91_RS05095 1037379..1038278 + 900 WP_000131779.1 ATP phosphoribosyltransferase -
HVY91_RS05100 1038284..1039588 + 1305 WP_002431466.1 histidinol dehydrogenase -
HVY91_RS05105 1039585..1040655 + 1071 WP_181669902.1 histidinol-phosphate transaminase -
HVY91_RS05110 1040655..1041722 + 1068 WP_181669903.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T165118 WP_000767829.1 NZ_CP057256:c1036651-1036397 [Escherichia fergusonii]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

>T165118 NZ_CP073715:837554-837952 [Salmonella enterica subsp. enterica serovar Bovismorbificans]
ATGCTGAAATTCATGCTTGATACCAATACCTGTATTTTCACCATCAAAAATAAGCCCGAACACATCAGAGAACGCTTCAA
CCTCAATACATCCCGAATGTGTATCAGCTCCATCACCTTAATGGAGCTGATTTACGGTGCTGAAAAAAGCCTGGCGCCGG
AGCGTAATCTTGCCGTCGTGGAGGGATTTATCTCCCGCCTGGAGGTTCTGGATTACGATACACAGGCAGCGATACATACC
GGTCAAATCCGTGCCGAACTGGCCCGCAAGGGAACACCTGTCGGGCCTTATGACCAGATGATTGCTGGCCATGCCCGTAG
CCGCGGACTGGTCGTCGTCACAAACAATCTCCGCGAGTTTGAACGCATTCCGGGTATCCGAATCGAAGACTGGTGCTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT165118 WP_001259255.1 NZ_CP057256:c1036899-1036648 [Escherichia fergusonii]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp

>AT165118 NZ_CP073715:837327-837554 [Salmonella enterica subsp. enterica serovar Bovismorbificans]
ATGCACACAACACTTTTTTTTAGTAACCGGACCCAGGCAGTCAGATTGCCTAAATCGATATCCTTTCCGGATGATGTGAA
ACATGTCGAAATCATTGCGGTTGGTAGAAGCAGAATCATTACTCCAGTCGGAGAATCCTGGGACAGCTGGTTCGATGGCG
AAGGCGCCAGTACTGATTTTATGAGTACCAGAGAACAACCCGCAGTACAGGAACGGGAAGGATTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6NY6
PDB 2A6S
PDB 6OXA
PDB 2A6R
PDB 4V8X
PDB 6OTR
PDB 6OXI
PDB 2A6Q

Antitoxin

Source ID Structure
PDB 2A6Q
AlphaFold DB A0A7U9LNR0

References