Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 483366..483928 Replicon chromosome
Accession NZ_CP057256
Organism Escherichia fergusonii strain RHB31-C17

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag HVY91_RS02380 Protein ID WP_181669796.1
Coordinates 483650..483928 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID S1PAQ1
Locus tag HVY91_RS02375 Protein ID WP_000781370.1
Coordinates 483366..483650 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HVY91_RS02360 478725..481772 + 3048 WP_181669795.1 formate dehydrogenase-N subunit alpha -
HVY91_RS02365 481785..482669 + 885 WP_148048370.1 formate dehydrogenase N subunit beta -
HVY91_RS02370 482662..483315 + 654 WP_000045648.1 formate dehydrogenase-N subunit gamma -
HVY91_RS02375 483366..483650 - 285 WP_000781370.1 HigA family addiction module antidote protein Antitoxin
HVY91_RS02380 483650..483928 - 279 WP_181669796.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HVY91_RS02385 484114..485124 - 1011 WP_000642407.1 alcohol dehydrogenase AdhP -
HVY91_RS02390 485259..486956 - 1698 WP_000433464.1 malate dehydrogenase -
HVY91_RS02395 487113..487250 - 138 WP_000841554.1 stationary-phase-induced ribosome-associated protein -
HVY91_RS02400 487352..487567 - 216 WP_000495766.1 biofilm-dependent modulation protein -
HVY91_RS02405 487911..488342 + 432 WP_000152305.1 peroxiredoxin OsmC -
HVY91_RS02410 488403..488543 + 141 WP_109043809.1 omptin family outer membrane protease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-88)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10565.16 Da        Isoelectric Point: 7.3562

>T165117 WP_181669796.1 NZ_CP057256:c483928-483650 [Escherichia fergusonii]
MIMNFRHKGLRDLFLLGKTSGVIPTQIKRLRHRLAVIDATSCLADLDMPGYRLHPLSGDRDGIWAISVSGNWRITFEFVN
GDAYILDYEDYH

Download         Length: 279 bp

>T165117 NZ_CP073715:827846-828259 [Salmonella enterica subsp. enterica serovar Bovismorbificans]
GTGGTCCTGTGGCAATCTGATTTACGCGTCTCATGGCGCGCTCAGTGGATCTCATTGCTCATTCATGGGCTGGTTGCCGC
GGTGATTTTATTGATGCCCTGGCCGCTGAGTTATACCCCGTTATGGATGATACTACTGTCGCTGGTCGTGTTTGACTGTG
TACGTAGCCAGCGCAGGATTAATACCTGCCAGGGAGAGATCAAGCTACTCATGGACGGGCGCTTACGCTGGCAGGGGCAG
GACTGGACGCTCTTGCGTCCGCCCTGGTTACTGAAGAGCGGGATGGTGTTGCGTTTACGCGCAGAGTCTGGACGTCATCA
GCATTTATGGCTGGCGGCGGATAGCATGGAAGAAGCGGAATGGCGTGAGTTGCGTCGGATACTGTTACAGCAGCCGATAT
CAGGCCAACACTGA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10401.08 Da        Isoelectric Point: 8.8567

>AT165117 WP_000781370.1 NZ_CP057256:c483650-483366 [Escherichia fergusonii]
MKMANHPRPGDIIQESLDELNVSLREFARAMEIAPSTASRLLTGKAALTPEMAIKLSVVIGSSPQMWLNLQNAWSLAEAE
KTVDVSRLRRLVTQ

Download         Length: 285 bp

>AT165117 NZ_CP073715:827599-827865 [Salmonella enterica subsp. enterica serovar Bovismorbificans]
ATGGATATTCACAATAAAGCACGTATTCACTGGGCATGTCGTCGCGGTATGCGCGAACTTGATATTTCCATCATGCCGTT
TTTTGAACATGAGTACGATAGTTTAAGTGATGAAGAAAAGCGTATTTTTGTCCGTTTGTTGCAGAGTGATGACCCGGATT
TATTTAACTGGTTAATGAATCACGGTAAACCGGCTGACGCTGAACTGGAACAGATGGTCCGACTCATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 2ICT
PDB 2ICP
AlphaFold DB A0A829CUG6

References