Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 31012..31873 Replicon plasmid pRHB32-C05_3
Accession NZ_CP057245
Organism Escherichia fergusonii strain RHB32-C05

Toxin (Protein)


Gene name yhaV Uniprot ID A0A7W3G1F8
Locus tag HVY96_RS23820 Protein ID WP_024195926.1
Coordinates 31379..31873 (+) Length 165 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID A0A7W3G1H0
Locus tag HVY96_RS23815 Protein ID WP_001559862.1
Coordinates 31012..31356 (+) Length 115 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HVY96_RS23785 26500..27108 - 609 WP_160520256.1 hypothetical protein -
HVY96_RS23790 27328..27828 + 501 WP_000528932.1 hypothetical protein -
HVY96_RS23795 27841..28614 + 774 WP_000905949.1 hypothetical protein -
HVY96_RS23800 28781..29914 + 1134 WP_181576151.1 DUF3800 domain-containing protein -
HVY96_RS23805 29948..30460 - 513 WP_000151784.1 hypothetical protein -
HVY96_RS23810 30691..30768 + 78 Protein_34 helix-turn-helix domain-containing protein -
HVY96_RS23815 31012..31356 + 345 WP_001559862.1 type II toxin-antitoxin system PrlF family antitoxin Antitoxin
HVY96_RS23820 31379..31873 + 495 WP_024195926.1 type II toxin-antitoxin system YhaV family toxin Toxin
HVY96_RS23825 32055..34811 + 2757 Protein_37 hypothetical protein -
HVY96_RS23830 34863..35560 + 698 Protein_38 IS1 family transposase -
HVY96_RS23835 35575..36639 + 1065 Protein_39 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - - 1..116001 116001


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(11-147)

Antitoxin

PrlF antitoxin

(16-114)


Sequences

Toxin        


Download         Length: 165 a.a.        Molecular weight: 19275.36 Da        Isoelectric Point: 8.7864

>T165103 WP_024195926.1 NZ_CP057245:31379-31873 [Escherichia fergusonii]
MEYLEINGWKICFHECFLRQITGLMKKVAELKASKPLEYHKKKETKLLVAIERVIEERITANPLDPQFRQGNTLGEEYKH
WFRAKFLMQFRLFYRCSQEHKTIVIGWVNGFDTLRAYDSRTDAYKVFGEMLKAGNPPDDWDTLLCEAGKATATTNMVDFL
TKRI

Download         Length: 495 bp

>T165103 NZ_CP073704:c2032712-2031816 [Burkholderia cenocepacia]
ATGAGTGTCATCGACAAACGTGAACGCGACCGCACCGCGGCGTTCGCCGCGCTGCTCGGGCAGTTTCCCGAGCAGCGTTG
CGCGGCCGGCGCGGCGGGCACGATCGGTTATCGCGAGGCCGGCGCGCAGCATGCGGGCCGCGCGCTGCCCGTCGTGCTGC
TGCACGGGATCGGCTCGGGCGCCGCGTCGTGGGTCCGTCAGCTCGACACGCTGGGCGCATCGCGGCGCGTGCTCGCGTGG
GATGCGCCCGGGTACGGCGTGTCGACGCCCGTGCACGGCGCGTCGCCGGCCGCCGCCGATTACGCGGCAGCGCTGAACGC
GTGGCTCGAGGCACTCGGCATCGAACGCTGCGTCCTGGTCGGCCATTCGCTCGGCGCGATCATCGCGGGCGGTCTCGCCC
GCGTGACGCCCGCGCGGATCGCCGGCCTGCTGCTGGTGTCGCCCGCGGGCGGCTACGGCAGCGCACCGGCCGAGACCCGC
GAAGCGCGCCGCGACGCGCGGCTCGCGATGCTCGCGGAACTCGGCCCGGCCGGGCTCGCCGAGCAGCGCAGCGGCAACAT
GCTGTCCGGTTTCGCGAACGAGGAGGCACGGGCGTGGGTGCGCTGGAACATGGCGCGCATCGTGCCGGCCGGCTATGCGC
AGGCCACGCATCTGCTCGCGAACGCCGATCTCGCGGCCGATCTCGCCGGCTTCCGGGGCCGCACGGCCGTGGCCGTCGGC
GCGAACGACGCGATCACGCCGCCCGCCGCGTGCGAGCGGATCGCCGCGGCCGCGCACGTCGGGCTGCAGGTGATTCCGCA
GGCAGGGCACGCCGGCTATGTGGAAGCGCCGGCCGCGTATTCCGCGCTGATCGACTCGTTCTGCCGGCAGTGCGATACGC
AGTGGGGGCTGGCATGA

Antitoxin


Download         Length: 115 a.a.        Molecular weight: 12755.59 Da        Isoelectric Point: 4.6652

>AT165103 WP_001559862.1 NZ_CP057245:31012-31356 [Escherichia fergusonii]
MATQILNSAEVSLRAESRLTERSQTTIPAVIRDALHLKPGEYIHYTLLAGGKVIMSRQNEEQDDPVISQFLTFLENDMKK
NPQKIAPVPTMFWESMKALTAGINVDLDAPLTED

Download         Length: 345 bp

>AT165103 NZ_CP073704:c2031777-2030920 [Burkholderia cenocepacia]
ATGAGCGAACCGCTGCAACAAAACGAATCCGAAAACGCGAAGGCCGAAGCCAGCTACGTGGTGCCGGGCCTCGAACGCGG
GTTGCGGATTCTCGCCGAATTCTCGCCGCGCGAGCCCGTGCTCGGCGCGCCTGAACTGTCGAAGCGGCTCGGCATTCCGC
GCACGACGGTGTTCCGTCTGCTGCAGACGCTCGAATCGCTCGGCTTTCTCGAACGCGCGGACAAGGATCGCAACTACAAG
CTCGGCATCGCCGTGCTGCGGCTCGGCTTCGAATACCTGAGCTCGCTGGAGCTGACCGATCTCGGCCTGCCGGTGATCGA
AAGCCTGCGCGATGCGACAGGCTTCACGACGCACATCGTGATCCGCGACGGCCGCGACGTGGTGTTCGTCGCGAAGGCGC
AGAGCCAGTCGCCGGTGTTCAGTTCGATCCGCGTGAACGTCGGCACCCGGCTGCCCGCGCATGCAACGACACACGGCCAC
GTGCTGATGGGCGACCTGTCGCTGAAGGAACTGCATGCGCTGTATCCGGAAGGCGTGCTGAACCGGATGACGAGCGCGAC
GCCGGAAACGGTCGACGCGCTGTACGAAGTGATCCGCGAGGATGCGCTGCGCGGCTACGGCGTCAGCAATTCGTCGTTCG
AGCGCGGGATCTCGGTCGTCACGGCGCCGGTGCGCAACGAGACGCAGAAGATCGTCGCTTGCATCACGGTGACGGTGCCG
CGTCCGGAGATCGACGCGGCGCTGATCGCGGACGGGCTGATCGACAAGGTGCAGCGCGCGGCGGCGGAACTGTCGCGGCG
GCTGAATTACCGCTCGGATGACGAGCACACGTTTCTCAAAGCTTTAGGACTCCGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7W3G1F8

Antitoxin

Source ID Structure
AlphaFold DB A0A7W3G1H0

References