Detailed information of TA system TA165093

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 70344..70598
• Replicon: plasmid pRHB32-C05_2
• Accession: NZ_CP057244
• Organism: Escherichia fergusonii strain RHB32-C05

Toxin (Protein)

• Gene name: srnB
• Uniprot ID: -
• Locus tag: HVY96_RS23195
• Protein ID: WP_001553767.1
• Coordinates: 70344..70550 (-)
• Length: 69 a.a.

Antitoxin (RNA)

Gene name	srnC
Locus tag	-
Coordinates	70537..70598 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HVY96_RS23170	67180..67461	-	282	WP_000969996.1	type II toxin-antitoxin system RelE/ParE family toxin	-
HVY96_RS23175	67458..67727	-	270	WP_000079941.1	hypothetical protein	-
HVY96_RS23180	68641..69498	-	858	WP_000131011.1	incFII family plasmid replication initiator RepA	-
HVY96_RS23185	69491..69565	-	75	WP_001365705.1	RepA leader peptide Tap	-
HVY96_RS23190	69812..70060	-	249	WP_000083838.1	replication regulatory protein RepA	-
HVY96_RS23195	70344..70550	-	207	WP_001553767.1	type I toxin-antitoxin system Hok family toxin	Toxin
-	70537..70598	+	62	NuclAT_1	-	Antitoxin
-	70537..70598	+	62	NuclAT_1	-	Antitoxin
-	70537..70598	+	62	NuclAT_1	-	Antitoxin
-	70537..70598	+	62	NuclAT_1	-	Antitoxin
HVY96_RS23200	71258..71719	-	462	WP_047649930.1	thermonuclease family protein	-
HVY96_RS23205	72462..72665	-	204	WP_040073114.1	hypothetical protein	-
HVY96_RS23210	72820..73377	-	558	WP_047649932.1	fertility inhibition protein FinO	-
HVY96_RS23215	73480..74340	-	861	WP_000704529.1	alpha/beta hydrolase	-
HVY96_RS23220	74399..75139	-	741	WP_094259392.1	conjugal transfer pilus acetylase TraX	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Conjugative plasmid	-	pefD / pefC / pefA	1..147532	147532

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (23-64)

Sequences

Toxin

Protein

• Length: 69 a.a.
• Molecular weight: 7804.35 Da
• Isoelectric Point: 8.8807

>T165093 WP_001553767.1 NZ_CP057244:c70550-70344 [Escherichia fergusonii]
MKYLNTTDCSLFLAERSKFMTKYALIGVLAVCATVLCFLLIFRERLCELNIHRGNTVVQVTLAYEARK

Nucleotide

• Length: 207 bp

>T165093 NZ_CP073702:1219728-1219979 [Burkholderia cenocepacia]
ATGCAACGGCTCCGCGAATTCCTGAGGCCGAAGAATCCCGATGCCGCGAGGCGGGCCGGCGAAGCGATTAGGCGCGGCGT
CCAGGCTCTCGGTGCCCACCCTCGAATGGGGCGGCTCATAGAAGATCTGCCTGAACAGTATCGGGAGTGGCTTATCGATT
TTGGGGATAGTGGCTATGTGGCTCGGTACCGCCTCGATGGCGATACCGTCACGATTTTGGCCGTGCGACACCAGAAGGAA
GCAGGGTACTGA

Antitoxin

Nucleotide

• Length: 62 bp

>AT165093 NZ_CP057244:70537-70598 [Escherichia fergusonii]
TTAAGGTACTTCATGCAGGCCTCACGAGTTAATGGATTAACAAGTGGGGTCTTCGCATTTCT

Structures

Antitoxin