Detailed information of TA system TA165090

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 4459833..4460091
• Replicon: chromosome
• Accession: NZ_CP057243
• Organism: Escherichia fergusonii strain RHB32-C05

Toxin (Protein)

• Gene name: hokA
• Uniprot ID: -
• Locus tag: HVY96_RS21760
• Protein ID: WP_001135723.1
• Coordinates: 4459833..4459985 (-)
• Length: 51 a.a.

Antitoxin (RNA)

Gene name	sokA
Locus tag	-
Coordinates	4460036..4460091 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HVY96_RS21735	4455692..4456402	-	711	WP_000190514.1	DUF3053 domain-containing protein	-
HVY96_RS21740	4456840..4458216	+	1377	WP_181666939.1	MFS transporter	-
HVY96_RS21745	4458466..4458756	+	291	WP_000455800.1	HTH-type transcriptional regulator	-
HVY96_RS21750	4459037..4459249	+	213	WP_000014594.1	RNA chaperone/antiterminator CspA	-
HVY96_RS21755	4459303..4459674	-	372	WP_001037804.1	membrane protein insertion efficiency factor YidD	-
HVY96_RS21760	4459833..4459985	-	153	WP_001135723.1	type I toxin-antitoxin system toxin HokA	Toxin
-	4460036..4460091	+	56	-	-	Antitoxin
HVY96_RS21765	4460308..4462377	-	2070	WP_001291792.1	glycine--tRNA ligase subunit beta	-
HVY96_RS21770	4462387..4463298	-	912	WP_001168544.1	glycine--tRNA ligase subunit alpha	-
HVY96_RS21775	4463394..4463693	-	300	WP_181667494.1	YsaB family lipoprotein	-
HVY96_RS21780	4463865..4464860	+	996	WP_002432855.1	acyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-46)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5899.14 Da
• Isoelectric Point: 6.9160

>T165090 WP_001135723.1 NZ_CP057243:c4459985-4459833 [Escherichia fergusonii]
MPQKYGLLSLIVICFTLLFFTWMIRDSLCELHIKQESYELAAFLACKLKE

Nucleotide

• Length: 153 bp

>T165090 NZ_CP073682:1496328-1496678 [Paenibacillus sp. S02]
TTGATCGTAAAGCGCGGCGACGTTTTTTTTGCAGACCTTTCACCCGTAGTCGGTTCCGAGCAAGGTGGCGTCAGACCTGT
GCTGATCATTCAAAATGATATCGGCAACCGGTTTAGTCCTACTGTGATCGTAGCAGCCATCACCGCCCAGATTCAGAAGG
CAAAGCTGCCTACACACGTGGAAATCGACGCGGCGACGCATGGCTTTGATCGTGATTCTGTTGTTCTTCTGGAGCAAATT
CGGACGATCGACAAGCAAAGGCTTACCGACAAAATCACCCATTTAGATGAAGAAACCATGCGCAAAGTGAGCGATTCGCT
ACAAATTAGTCTCGGTTTGATTGATTTTTAG

Antitoxin

Nucleotide

• Length: 56 bp

>AT165090 NZ_CP057243:4460036-4460091 [Escherichia fergusonii]
GTTGAAGCATAGAGGCAGCCTCACTTTGATTTATAGTCAGGTGGGGCTTTTCTCTG

Structures

Antitoxin