Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yafN-yafO (relBE)/YafO-YafN
Location 3595890..3596584 Replicon chromosome
Accession NZ_CP057243
Organism Escherichia fergusonii strain RHB32-C05

Toxin (Protein)


Gene name yafO Uniprot ID -
Locus tag HVY96_RS17545 Protein ID WP_181666723.1
Coordinates 3595890..3596288 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name yafN Uniprot ID -
Locus tag HVY96_RS17550 Protein ID WP_181666724.1
Coordinates 3596291..3596584 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HVY96_RS17515 3591018..3592475 + 1458 WP_001293012.1 cytosol nonspecific dipeptidase -
HVY96_RS17520 3592484..3592765 + 282 WP_000106440.1 hypothetical protein -
HVY96_RS17525 3592774..3593298 - 525 WP_141095971.1 metal-dependent hydrolase -
HVY96_RS17530 3593360..3593974 - 615 WP_046076930.1 peptide chain release factor H -
HVY96_RS17535 3593971..3595110 - 1140 WP_181666722.1 RNA ligase RtcB family protein -
HVY96_RS17540 3595428..3595880 - 453 WP_001059848.1 GNAT family N-acetyltransferase -
HVY96_RS17545 3595890..3596288 - 399 WP_181666723.1 type II toxin-antitoxin system mRNA interferase toxin YafO Toxin
HVY96_RS17550 3596291..3596584 - 294 WP_181666724.1 type I toxin-antitoxin system antitoxin YafN Antitoxin
HVY96_RS17555 3596636..3597691 - 1056 WP_001226157.1 DNA polymerase IV -
HVY96_RS17560 3597762..3598547 - 786 WP_181666725.1 putative lateral flagellar export/assembly protein LafU -
HVY96_RS17565 3598492..3600231 + 1740 WP_181666726.1 flagellar biosynthesis protein FlhA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin YafO

(27-130)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 15516.93 Da        Isoelectric Point: 8.9401

>T165085 WP_181666723.1 NZ_CP057243:c3596288-3595890 [Escherichia fergusonii]
MRVFKTKLIRLQLTAKELDALTADFISYKRDSVLPDIFGRDALYDDSFTWPLIKFERVAHIHLANENNPFPPQLRQFSRT
NDEAHLVYCQGAFDEQAWLLIAILKPEPHKLARDNNQMHKIGKMAEAFRMRF

Download         Length: 399 bp

>T165085 NZ_CP073677:c3222557-3222147 [Cupriavidus sp. KK10]
ATGACGCGCTACATGCTCGACACCAATATCGTGAGCCACCTGCTGCGGGCACATCCGGCAGTCGTGGCACGCGTGACGGC
CGCGCCGATGGCGGCGCTGTGCCTGTCAGCCATCACCGGCGCGGAACTGATGTACGGGCTGGCCAAACGCCCCGGTGCAG
CGCGCCTCGCGCGCGCAGTCGACGAACTGCTGCGCAGGGTCGAGGTGTTGCCCTGGACCCCTTCAGTAATGGTCGGCTAT
GGTGAGACCCGCGCTGCGCTGGAATCCCAAGGACAGCCAATGGGGGCACTGGACTTGCTGATTGCCGCGCACGCGCTGGA
GACTGGTGCGGTGCTGGTGACCAATGACCAGGCGTTCCGGCGCGTTCCTGGCCTGGTGGTGGAGGACTGGTCGGTTCCGA
CCGGAAACTGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11267.82 Da        Isoelectric Point: 5.9050

>AT165085 WP_181666724.1 NZ_CP057243:c3596584-3596291 [Escherichia fergusonii]
MHRILAEKSVNITELRKNPAKYFIDQPVAVLSNNRPAGYLLSASAFEALMDMLAEQEEKKPIKARFRPSAARLEEITRRA
EKYFNDMTDDDFNDFKE

Download         Length: 294 bp

>AT165085 NZ_CP073677:c3222805-3222554 [Cupriavidus sp. KK10]
GTGAGCACCACTGCCAAAATTTTCACCACTGGCCGCAGCCAGGCGGTACGGCTGCCGCAGGAATTCCGCTTCGCCGAGCG
CGAGGTATATATACGCCGCGACCCGTCCACCGGCGACGTGATCCTGTCGCGCCGGCCGGAGAGTTGGGACGGCTTCCTGG
CAGCCATCAAGGACAGCGCCGTGCCGGCAGACTTCCTGGCCGGCCGCGCGCAGGGCGAACAAGCCAGGGATCCGCTGGCG
GGCCTCGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References