Detailed information of TA system TA165082

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 2825375..2825600
• Replicon: chromosome
• Accession: NZ_CP057243
• Organism: Escherichia fergusonii strain RHB32-C05

Toxin (Protein)

• Gene name: hokW
• Uniprot ID: S1ELB5
• Locus tag: HVY96_RS13800
• Protein ID: WP_000813254.1
• Coordinates: 2825375..2825530 (-)
• Length: 52 a.a.

Antitoxin (RNA)

Gene name	sokW
Locus tag	-
Coordinates	2825542..2825600 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HVY96_RS13745	2820958..2821176	-	219	WP_181666550.1	class II holin family protein	-
HVY96_RS13770	2821973..2822662	-	690	WP_096215950.1	antiterminator	-
HVY96_RS13775	2822659..2823024	-	366	WP_000139994.1	RusA family crossover junction endodeoxyribonuclease	-
HVY96_RS13780	2823025..2824080	-	1056	WP_181666551.1	DUF968 domain-containing protein	-
HVY96_RS13785	2824082..2824360	-	279	WP_097419052.1	hypothetical protein	-
HVY96_RS13790	2824476..2824961	-	486	WP_000818167.1	type II toxin-antitoxin system death-on-curing family toxin	-
HVY96_RS13795	2824980..2825159	-	180	WP_001277774.1	hypothetical protein	-
HVY96_RS13800	2825375..2825530	-	156	WP_000813254.1	type I toxin-antitoxin system toxin HokD	Toxin
-	2825542..2825600	+	59	-	-	Antitoxin
HVY96_RS13805	2826107..2827015	+	909	WP_001297700.1	bacteriophage abortive infection AbiH family protein	-
HVY96_RS13810	2827105..2828497	+	1393	Protein_2691	hypothetical protein	-
HVY96_RS13815	2828760..2829182	-	423	WP_162522223.1	DUF977 family protein	-
HVY96_RS13820	2829223..2830293	-	1071	WP_001262357.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2795763..2841395	45632

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-47)

Sequences

Toxin

Protein

• Length: 52 a.a.
• Molecular weight: 5736.89 Da
• Isoelectric Point: 6.1531

>T165082 WP_000813254.1 NZ_CP057243:c2825530-2825375 [Escherichia fergusonii]
MKQQKAMLIALIVICLTVIVTALVTRKDLCEVRIRTGQTEVAVFTAYEPEE

Nucleotide

• Length: 156 bp

>T165082 NZ_CP073677:c1405874-1405596 [Cupriavidus sp. KK10]
ATGATCACTTCGTTCAACTGCCGCGACACGGCACTGCTCTTCGCAGGCACGCGGATCGCCCGGTTCGTCAACATAGAATC
TGTTGCCATGCGCAAGCTCCAGCAGTTGCACGCGGCCGGCGACCTCAGCTTTCTGCGAGTCCCGCCGGGTAACAGGCTGG
AAGCGCTGCAAGGGCACCGGGCTGGTCAGCACAGCATCCGTATCAACGACCAATGGCGAATCTGCTTTTGCTTCGCCAAT
GGCCATGCAACTGACGTCGAGATCGTCGACTACCACTGA

Antitoxin

Nucleotide

• Length: 59 bp

>AT165082 NZ_CP057243:2825542-2825600 [Escherichia fergusonii]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTAGATTTGCCGTTCATAGATTGAGCCTCA

Structures

Toxin

• AlphaFold DB: A0A4P7TMW0

Antitoxin