Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 584164..584963 Replicon chromosome
Accession NZ_CP057243
Organism Escherichia fergusonii strain RHB32-C05

Toxin (Protein)


Gene name yhaV Uniprot ID U9XVR9
Locus tag HVY96_RS02775 Protein ID WP_000347267.1
Coordinates 584164..584628 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID B7LMV4
Locus tag HVY96_RS02780 Protein ID WP_015953962.1
Coordinates 584628..584963 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HVY96_RS02745 579166..579600 - 435 WP_181667088.1 PTS sugar transporter subunit IIA -
HVY96_RS02750 579618..580496 - 879 WP_001295548.1 PTS system mannose/fructose/sorbose family transporter subunit IID -
HVY96_RS02755 580486..581265 - 780 WP_000406214.1 PTS mannose/fructose/sorbose/N-acetylgalactosamine transporter subunit IIC -
HVY96_RS02760 581276..581749 - 474 WP_181667089.1 PTS N-acetylgalactosamine transporter subunit IIB -
HVY96_RS02765 581772..583052 - 1281 WP_180491940.1 tagatose-bisphosphate aldolase subunit KbaZ -
HVY96_RS02770 583300..584109 + 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
HVY96_RS02775 584164..584628 - 465 WP_000347267.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
HVY96_RS02780 584628..584963 - 336 WP_015953962.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
HVY96_RS02785 585112..586683 - 1572 WP_181667090.1 galactarate dehydratase -
HVY96_RS02790 587154..587924 + 771 WP_001058567.1 2-dehydro-3-deoxyglucarate aldolase -
HVY96_RS02795 587949..588839 + 891 WP_000178100.1 2-hydroxy-3-oxopropionate reductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17807.17 Da        Isoelectric Point: 9.4947

>T165064 WP_000347267.1 NZ_CP057243:c584628-584164 [Escherichia fergusonii]
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWESLTQETEENH

Download         Length: 465 bp

>T165064 NZ_CP073671:65197-65607 [Burkholderia cenocepacia]
ATGACGCTGTATCTGCTCGACACCAACATCTTGTCGAACGTGATCCGCGACCCGCGTGGCGCCTGCGCCACCCGCATCGG
ACAAATGCCGCCCGAACAAGTGTGCACCTCGATCATCGTCGCCGCGGAGTTGCGATTTGGCGTCTGGAAGCGTGGCTCGT
CGACCCTCGCCCAGCGGGTCGAGCAACTGCTCGCGAGCTTGACCGTGTTGCCGTTGCAGCCCGACGCCGACCGGTGCTAC
GGCCGGTTGCGGGCTGACCTCGAGAAGCAAGGCCAGCTGATCGGCGCCAACGATATGCTGATCGCCGCGCACGCTCTGGC
GGTTGACGCCGTCCTGGTCACGGACAATACGGCCGAATTTACCCGTGTCTCCGGCCTGCCGGTCGAAAACTGGTTGCGAC
CGGCGACCTAA

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12281.89 Da        Isoelectric Point: 4.4128

>AT165064 WP_015953962.1 NZ_CP057243:c584963-584628 [Escherichia fergusonii]
MPANARSNAVLTTESKVTIRGQTTIPAPVREALKLKPGLDSIHYEILPGGQVFMCRLGDEQEDPTMNAFLRFLDADIQNN
PQKTRPFDIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp

>AT165064 NZ_CP073671:64958-65200 [Burkholderia cenocepacia]
ATGCCAACCCATGACACCCGCCACGCGCGCCTGTTTCGCAATGGGCGCAGCCAGGCCGTGCGGATCCCGCGCGAGTTCGA
GCTGCCGGTCTCGGAAGTCACCATCCACCGGGAAGGCAGGCGCCTGATCATCGAACCGGTGGAAGCCGCGCCGTTGCGCG
AGCTGTTCGCCCAATGGACCCCGCTGGACGAGACCTTTCCGGACATCGAGGACCTTCCACCTGAACCGGTCGACATCGAA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0XTR4

Antitoxin

Source ID Structure
AlphaFold DB B7LMV4

References