Detailed information of TA system TA165051

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HigB-HTH_XRE
• Location: 3989418..3990097
• Replicon: chromosome
• Accession: NZ_CP057238
• Organism: Escherichia fergusonii strain RHB32-C09

Toxin (Protein)

• Gene name: higB
• Uniprot ID: B7LJF3
• Locus tag: HVZ00_RS19250
• Protein ID: WP_002431667.1
• Coordinates: 3989418..3989720 (+)
• Length: 101 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: HVZ00_RS19255
• Protein ID: WP_000806440.1
• Coordinates: 3989756..3990097 (+)
• Length: 114 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HVZ00_RS19225	3984794..3986446	+	1653	WP_181668258.1	bifunctional UDP-sugar hydrolase/5'-nucleotidase	-
HVZ00_RS19230	3986484..3986987	-	504	WP_181668259.1	hypothetical protein	-
HVZ00_RS19235	3986984..3987784	-	801	WP_181668260.1	hypothetical protein	-
HVZ00_RS19240	3987808..3988287	-	480	WP_181668261.1	Cys-tRNA(Pro)/Cys-tRNA(Cys) deacylase YbaK	-
HVZ00_RS19245	3988491..3989285	-	795	WP_000365145.1	TraB/GumN family protein	-
HVZ00_RS19250	3989418..3989720	+	303	WP_002431667.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
HVZ00_RS19255	3989756..3990097	+	342	WP_000806440.1	HigA family addiction module antidote protein	Antitoxin
HVZ00_RS19260	3990211..3992715	-	2505	WP_181668262.1	copper-exporting P-type ATPase CopA	-
HVZ00_RS19265	3993022..3994311	+	1290	WP_000102764.1	APC family permease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-1 (9-98)

Antitoxin

• Cro/C1-type helix-turn-helix domain (16-70)

Sequences

Toxin

Protein

• Length: 101 a.a.
• Molecular weight: 11811.37 Da
• Isoelectric Point: 10.1572

>T165051 WP_002431667.1 NZ_CP057238:3989418-3989720 [Escherichia fergusonii]
MAQKNNIRSFRDAWLADFFVHSTPHRKIPAEIHTTLSRKLDIINAATSHRDLRSPPGNRYEELSGKLQEYSSIRVNKQYR
LIFKWVNGKAEELYLDPHNY

Nucleotide

• Length: 303 bp

>T165051 NZ_CP073667:c1646417-1645521 [Burkholderia contaminans]
ATGAGTGTCATCGACAAACGTGAACGCGACCGCACCGCGGCGTTCGCCGCGCTGCTCGGGCAGTTCCCCGAACAGCGTTG
CGCGGCCGGCGCGGCGGGCACGATCGGATATCGCGAGGCCGGCGCGCACCATGCGGGCCGTGCGTTGCCCGTCGTGCTGC
TGCACGGCATCGGCTCGGGCGCCGCATCGTGGGTGCGCCAGCTCGACACGCTCGGCGCATCGCGGCGCGTGCTCGCGTGG
GATGCGCCCGGTTACGGCGTGTCGACGCCGGTGCACGGCGCGTCGCCGGCCGCCACCGATTACGCGGCATCGCTGAACGC
GTGGCTCGAGGCACTCGGCATCGAACGCTGCGTGCTGGTCGGTCATTCGCTCGGCGCGATCATCGCGGGCGGTCTCATCC
GCGTGATGCCCGCGCGGATCGCCGGCCTGCTGCTGGTGTCGCCCGCGGGCGGCTACGGCAGCGCACCGGCCGAAACGCGC
GACGCGCGCCGCGACGCGCGGCTCGCGATGCTCGCCGAACTCGGCCCGGCCGGGCTCGCCGAGCAGCGCAGCGGCAACAT
GCTGTCCGGTTTCGCGAACGAGGATGCGCGTGCGTGGGTGCGCTGGAACATGGCGCGCATCGTGCCGGCCGGCTACGCGC
AGGCCACGCAACTGCTCGCGAATGCCGATCTCGCAACGGATCTCGCCGGCTTTCGCGGCCGCACGGCCGTGGCCGTCGGC
GCGAACGACGCGATCACGCCGCCCGCCGCGTGCGAGCGGATTGCCGCGGCCGCGCACGTCGGGCTGCAGGTGATTCCACA
AGCGGGCCATGCCGGCTACGTGGAAGCACCGGCCGTCTATTCCGCACTGATCGACGCGTTCTGCCGTCAGTGCGACCAAC
AGCGGGGGCTGGCATGA

Antitoxin

Protein

• Length: 114 a.a.
• Molecular weight: 13157.08 Da
• Isoelectric Point: 5.7737

>AT165051 WP_000806440.1 NZ_CP057238:3989756-3990097 [Escherichia fergusonii]
MKQATRKPTTPGDILLYEYLEPLDLKINELAELLHVHRNSVSALINNNRKLTTEMAFRLAKVFDTTVDFWLNLQAAVDLW
EVENNMRTQEELGRIETVADYLARREERAKKVA

Nucleotide

• Length: 342 bp

>AT165051 NZ_CP073667:c1645524-1644667 [Burkholderia contaminans]
ATGAACGAACCGCTGCAACGACCCGAACTCGAAAACGGCAAGGCCGAAGCCAGCTACGTGGTGCCCGGCCTCGAACGCGG
GCTGCGGATTCTCGCCGAATTCTCGCCGCGCGAGCCCGTGCTCGGCGCGCCCGAATTGTCGAAGCGGCTCGGCATTCCGC
GCACGACGGTGTTCCGTCTGCTGCAGACGCTCGAATCGCTCGGCTTCCTCGAGCGCGCGGACAAGGATCGCAACTACAAG
CTCGGCATCGCCGTGCTGCGGCTCGGTTTCGAATACCTGAGCTCGCTGGAGCTGACCGATCTCGGCCTGCCCGTGATCGA
AAGCCTGCGCGATGCGACCGGCTTCACGACGCACATCGTGATCCGTGACGGCCGCGACGTGGTGTTCGTCGCGAAGGCGC
AGAGCCAGGCGCCGGTGTTCAGCTCGATCCGCGTGAACGTCGGGACGCGCTTGCCCGCACATGCGACGACGCACGGTCAC
GTGCTGATGGGCGACCTGTCGTTGAAGGAACTGCATGCGCTGTATCCGGAAGGCACGCTGAACCGCATGACGAACGCGAC
GCCGGAAACGGTCGATGCGCTGTACGAAGTGATCCGCGAGGATGCGCTGCGCGGCTACGGCGTCAGCAATTCGTCGTTCG
AGCGCGGCATCTCGGTGGTCACCGCGCCGGTGCGTAACGAGACACAGAGGATCGTGGCGTGCATCACGGTGACGGTGCCG
AGGCCGGAAATCGACGCGGCGCTGATCGCGGACGGCCTGATCGACAAGGTACAGCGCGCGGCGGCGGAACTGTCGCGGCG
GCTCAATTACCGCTCGGATGACGAGCACACGTTTTTGAAGGCTTTAGGACTCCGATGA

Structures

Toxin

• AlphaFold DB: A0A7K4HYG8