Detailed information of TA system TA165044

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): ldrD-rdlD/Ldr(toxin)
• Location: 2532988..2533207
• Replicon: chromosome
• Accession: NZ_CP057238
• Organism: Escherichia fergusonii strain RHB32-C09

Toxin (Protein)

• Gene name: ldrD
• Uniprot ID: S1NWX0
• Locus tag: HVZ00_RS12235
• Protein ID: WP_001295224.1
• Coordinates: 2532988..2533095 (-)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	rdlD
Locus tag	-
Coordinates	2533144..2533207 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HVZ00_RS12210	2528235..2529002	-	768	WP_000279500.1	cellulose biosynthesis protein BcsQ	-
HVZ00_RS12215	2529014..2529202	-	189	WP_001063310.1	YhjR family protein	-
HVZ00_RS12220	2529489..2531048	+	1560	WP_001070267.1	cellulose biosynthesis protein BcsE	-
HVZ00_RS12225	2531045..2531236	+	192	WP_000981122.1	cellulose biosynthesis protein BcsF	-
HVZ00_RS12230	2531233..2532912	+	1680	WP_000192007.1	cellulose biosynthesis protein BcsG	-
HVZ00_RS12235	2532988..2533095	-	108	WP_001295224.1	type I toxin-antitoxin system toxin Ldr family protein	Toxin
-	2533144..2533207	+	64	NuclAT_10	-	Antitoxin
-	2533144..2533207	+	64	NuclAT_10	-	Antitoxin
-	2533144..2533207	+	64	NuclAT_10	-	Antitoxin
-	2533144..2533207	+	64	NuclAT_10	-	Antitoxin
-	2533144..2533207	+	64	NuclAT_11	-	Antitoxin
-	2533144..2533207	+	64	NuclAT_11	-	Antitoxin
-	2533144..2533207	+	64	NuclAT_11	-	Antitoxin
-	2533144..2533207	+	64	NuclAT_11	-	Antitoxin
-	2533144..2533207	+	64	NuclAT_12	-	Antitoxin
-	2533144..2533207	+	64	NuclAT_12	-	Antitoxin
-	2533144..2533207	+	64	NuclAT_12	-	Antitoxin
-	2533144..2533207	+	64	NuclAT_12	-	Antitoxin
-	2533144..2533207	+	64	NuclAT_13	-	Antitoxin
-	2533144..2533207	+	64	NuclAT_13	-	Antitoxin
-	2533144..2533207	+	64	NuclAT_13	-	Antitoxin
-	2533144..2533207	+	64	NuclAT_13	-	Antitoxin
-	2533144..2533209	+	66	NuclAT_8	-	-
-	2533144..2533209	+	66	NuclAT_8	-	-
-	2533144..2533209	+	66	NuclAT_8	-	-
-	2533144..2533209	+	66	NuclAT_8	-	-
-	2533144..2533209	+	66	NuclAT_9	-	-
-	2533144..2533209	+	66	NuclAT_9	-	-
-	2533144..2533209	+	66	NuclAT_9	-	-
-	2533144..2533209	+	66	NuclAT_9	-	-
HVZ00_RS12240	2533531..2534727	+	1197	WP_181667966.1	methionine gamma-lyase	-
HVZ00_RS12245	2534977..2536275	+	1299	WP_181667967.1	amino acid permease	-
HVZ00_RS12250	2536291..2537502	-	1212	WP_181667968.1	sigma 54-interacting transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Type I toxin-antitoxin system, toxin Ldr (1-35)

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 3882.70 Da
• Isoelectric Point: 9.0157

>T165044 WP_001295224.1 NZ_CP057238:c2533095-2532988 [Escherichia fergusonii]
MTLAELGMAFWHDLAAPVIAGILASMIVNWLNKRK

Nucleotide

• Length: 108 bp

>T165044 NZ_CP073664:501651-502001 [Burkholderia contaminans]
ATGGTGAGGCGCGTCAAGTTCGAGAGGGGCGATATTGTGCGCGTTAGCCTGAACCCGACCGTGGGCAAGGAGCAACAAGG
GGATTTTCGCCCCGCGCTCGTTTTGTCGCCTGCTGCGTTCAATGCGCTTGGCGTGGCGCTCGTCGCGCCGATTACGCAGG
GCGGCGAATTCGCGCGATACGCGGGATTCGCTGTGCCCCTCTCGGGTTCGGGCACTGAAACGCAGGGCGTGGCTCTTGTG
AACATGGTTCGCACGCTCGATCTTCAGGCGCGTGGCGCACGTAAGGTCGAGCGCGCTCCGTCCGAAGTGATCGAAGATGC
GCTCGCGCGTCTTCAGACCATTCTCGAATAA

Antitoxin

Nucleotide

• Length: 64 bp

>AT165044 NZ_CP057238:2533144-2533207 [Escherichia fergusonii]
GTCTAGAGTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTT

Structures

Toxin

• AlphaFold DB: A0A4P7TSJ7

Antitoxin