Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 1053138..1053640 Replicon chromosome
Accession NZ_CP057238
Organism Escherichia fergusonii strain RHB32-C09

Toxin (Protein)


Gene name yoeB Uniprot ID U9YDH0
Locus tag HVZ00_RS05155 Protein ID WP_000767829.1
Coordinates 1053138..1053392 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag HVZ00_RS05160 Protein ID WP_001259255.1
Coordinates 1053389..1053640 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HVZ00_RS05125 1048154..1048381 - 228 WP_000985273.1 sulfurtransferase TusA family protein -
HVZ00_RS05130 1048395..1049453 - 1059 WP_181667654.1 transport protein YeeE -
HVZ00_RS05135 1049632..1050990 - 1359 WP_000019201.1 putrescine/proton symporter PlaP -
HVZ00_RS05140 1050980..1051042 - 63 WP_010723108.1 membrane protein YoeI -
HVZ00_RS05145 1051256..1052185 - 930 WP_000803361.1 LysR family transcriptional regulator -
HVZ00_RS05150 1052231..1053055 - 825 WP_000754745.1 SDR family oxidoreductase -
HVZ00_RS05155 1053138..1053392 - 255 WP_000767829.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
HVZ00_RS05160 1053389..1053640 - 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
HVZ00_RS05165 1053924..1053974 + 51 WP_001364200.1 his operon leader peptide -
HVZ00_RS05170 1054120..1055019 + 900 WP_000131779.1 ATP phosphoribosyltransferase -
HVZ00_RS05175 1055025..1056329 + 1305 WP_181667655.1 histidinol dehydrogenase -
HVZ00_RS05180 1056326..1057396 + 1071 WP_181667656.1 histidinol-phosphate transaminase -
HVZ00_RS05185 1057396..1058463 + 1068 WP_181667657.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T165041 WP_000767829.1 NZ_CP057238:c1053392-1053138 [Escherichia fergusonii]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

>T165041 NZ_CP073662:c31824-31525 [Pseudomonas sp. JS425]
ATGAAAGAGCAATTTTACGACTACGACCCCGCTGATGCGTTGACTGATGCGGAGTCCATCGCGGTATTCATGGAGGACGC
ATTCGAAACGGGCGATGCGGCCTATATCGCAAAATGCCTGGGTGTCGTAGCCCGCGCCAAAGGGATGACCGCCCTTGCCA
ATGAATCTGGCCTTTCCCGCGAACACCTCTACCGGTCGTTCTCGGACAAGGGCAACCCGACTTTGAAAACCCTGCTGGCC
GTGATGCGTGCCGTTGGCCTGGATCTTACGACCCGCAAGCACGTTGAGCCGGTGCACTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT165041 WP_001259255.1 NZ_CP057238:c1053640-1053389 [Escherichia fergusonii]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp

>AT165041 NZ_CP073662:c32123-31821 [Pseudomonas sp. JS425]
ATGAAGACAATTAAACAAACCGCCACGTACAGGAACTGGGAACGCAAGCTGCGAGACAAGCAGGCCAAAGCCATCATCGC
TGCGCGAGTCTTCCGCGTTGCGCATGGTCTGCTTGGAGACGTTCAACCGGTGGGCCAAGGAATCAGCGAATTACGCATCC
ATCACGGCCCCGGCTACCGGGTGTATTTTCAGCAGCGAGGTAACCAGCTGGTCCTGTTGCTGTGTGGTGGAGACAAGAGC
AGCCAAGCGCGGGATATCGAAACCGCCAAAGCCTTGGCCAGCCAGTGGAGTGACGATGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6NY6
PDB 2A6S
PDB 6OXA
PDB 2A6R
PDB 4V8X
PDB 6OTR
PDB 6OXI
PDB 2A6Q

Antitoxin

Source ID Structure
PDB 2A6Q
AlphaFold DB A0A7U9LNR0

References