Detailed information of TA system TA164991

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): ldrD-rdlD/Ldr(toxin)
• Location: 4316008..4316227
• Replicon: chromosome
• Accession: NZ_CP057220
• Organism: Escherichia fergusonii strain RHB32-C22

Toxin (Protein)

• Gene name: ldrD
• Uniprot ID: S1NWX0
• Locus tag: HVZ07_RS20800
• Protein ID: WP_001295224.1
• Coordinates: 4316008..4316115 (-)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	rdlD
Locus tag	-
Coordinates	4316164..4316227 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HVZ07_RS20775	4311255..4312022	-	768	WP_000279500.1	cellulose biosynthesis protein BcsQ	-
HVZ07_RS20780	4312034..4312222	-	189	WP_001063310.1	YhjR family protein	-
HVZ07_RS20785	4312509..4314068	+	1560	WP_001070267.1	cellulose biosynthesis protein BcsE	-
HVZ07_RS20790	4314065..4314256	+	192	WP_000981122.1	cellulose biosynthesis protein BcsF	-
HVZ07_RS20795	4314253..4315932	+	1680	WP_000192007.1	cellulose biosynthesis protein BcsG	-
HVZ07_RS20800	4316008..4316115	-	108	WP_001295224.1	type I toxin-antitoxin system toxin Ldr family protein	Toxin
-	4316164..4316227	+	64	NuclAT_10	-	Antitoxin
-	4316164..4316227	+	64	NuclAT_10	-	Antitoxin
-	4316164..4316227	+	64	NuclAT_10	-	Antitoxin
-	4316164..4316227	+	64	NuclAT_10	-	Antitoxin
-	4316164..4316227	+	64	NuclAT_11	-	Antitoxin
-	4316164..4316227	+	64	NuclAT_11	-	Antitoxin
-	4316164..4316227	+	64	NuclAT_11	-	Antitoxin
-	4316164..4316227	+	64	NuclAT_11	-	Antitoxin
-	4316164..4316227	+	64	NuclAT_12	-	Antitoxin
-	4316164..4316227	+	64	NuclAT_12	-	Antitoxin
-	4316164..4316227	+	64	NuclAT_12	-	Antitoxin
-	4316164..4316227	+	64	NuclAT_12	-	Antitoxin
-	4316164..4316227	+	64	NuclAT_13	-	Antitoxin
-	4316164..4316227	+	64	NuclAT_13	-	Antitoxin
-	4316164..4316227	+	64	NuclAT_13	-	Antitoxin
-	4316164..4316227	+	64	NuclAT_13	-	Antitoxin
-	4316164..4316229	+	66	NuclAT_8	-	-
-	4316164..4316229	+	66	NuclAT_8	-	-
-	4316164..4316229	+	66	NuclAT_8	-	-
-	4316164..4316229	+	66	NuclAT_8	-	-
-	4316164..4316229	+	66	NuclAT_9	-	-
-	4316164..4316229	+	66	NuclAT_9	-	-
-	4316164..4316229	+	66	NuclAT_9	-	-
-	4316164..4316229	+	66	NuclAT_9	-	-
HVZ07_RS20805	4316551..4317747	+	1197	WP_181667966.1	methionine gamma-lyase	-
HVZ07_RS20810	4317997..4319295	+	1299	WP_181667967.1	amino acid permease	-
HVZ07_RS20815	4319311..4320522	-	1212	WP_181667968.1	sigma 54-interacting transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Type I toxin-antitoxin system, toxin Ldr (1-35)

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 3882.70 Da
• Isoelectric Point: 9.0157

>T164991 WP_001295224.1 NZ_CP057220:c4316115-4316008 [Escherichia fergusonii]
MTLAELGMAFWHDLAAPVIAGILASMIVNWLNKRK

Nucleotide

• Length: 108 bp

>T164991 NZ_CP073625:c92099-91719 [Escherichia coli]
ATGAGGCATATATCACCGGAAGAACTTATTGCGCTTCATGATGCGAATATAAACCGCTACGGCGGCCTGCCGGGCATGTC
AGATCCGGGTAGGGCAGAGGCCATTATCGGGAGAGTTCAGGCCAGAGTTGCCTACGAAGAGATCACCGACCTTTTCGAAG
TCTCCGCCACCTACCTGGTGGCTACAGCGAGAGGGCATATATTCAATGATGCCAATAAGCGTACCGCGCTAAACAGTGCG
CTGTTATTTCTACGCCGTAACGGGGTGCAGGTATTTGATTCACCTGAACTGGCAGACCTTACCGTAGGGGCTGCGACCGG
AGAGATATCTGTATCTTCTGTCGCCGACACGTTACGTAGATTGTATGGTTCTGCGGAGTAG

Antitoxin

Nucleotide

• Length: 64 bp

>AT164991 NZ_CP057220:4316164-4316227 [Escherichia fergusonii]
GTCTAGAGTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTT

Structures

Toxin

• AlphaFold DB: A0A4P7TSJ7

Antitoxin