Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 2805313..2805815 Replicon chromosome
Accession NZ_CP057220
Organism Escherichia fergusonii strain RHB32-C22

Toxin (Protein)


Gene name yoeB Uniprot ID U9YDH0
Locus tag HVZ07_RS13505 Protein ID WP_000767829.1
Coordinates 2805313..2805567 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag HVZ07_RS13510 Protein ID WP_001259255.1
Coordinates 2805564..2805815 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HVZ07_RS13475 2800329..2800556 - 228 WP_000985273.1 sulfurtransferase TusA family protein -
HVZ07_RS13480 2800570..2801628 - 1059 WP_181667654.1 transport protein YeeE -
HVZ07_RS13485 2801807..2803165 - 1359 WP_000019201.1 putrescine/proton symporter PlaP -
HVZ07_RS13490 2803155..2803217 - 63 WP_010723108.1 membrane protein YoeI -
HVZ07_RS13495 2803431..2804360 - 930 WP_000803361.1 LysR family transcriptional regulator -
HVZ07_RS13500 2804406..2805230 - 825 WP_000754745.1 SDR family oxidoreductase -
HVZ07_RS13505 2805313..2805567 - 255 WP_000767829.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
HVZ07_RS13510 2805564..2805815 - 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
HVZ07_RS13515 2806099..2806149 + 51 WP_001364200.1 his operon leader peptide -
HVZ07_RS13520 2806295..2807194 + 900 WP_000131779.1 ATP phosphoribosyltransferase -
HVZ07_RS13525 2807200..2808504 + 1305 WP_181667655.1 histidinol dehydrogenase -
HVZ07_RS13530 2808501..2809571 + 1071 WP_181667656.1 histidinol-phosphate transaminase -
HVZ07_RS13535 2809571..2810638 + 1068 WP_181667657.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T164988 WP_000767829.1 NZ_CP057220:c2805567-2805313 [Escherichia fergusonii]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

>T164988 NZ_CP073624:c4193412-4193125 [Escherichia coli]
ATGCCAATGGAGTTTGAATGGGATGAAAACAAGGCCAAAAGTAATCGGGTGAAACATGGCATCCGCTTTGAAGATGCGGT
GTTATTGTTTGATGATCCACAACATTTGTCACAGCAAGAACGCATAGAAAACGGTGAGTATCGCTGGCAGACAATCGGCC
TGGTTTACGGCATCGTGGTTATTCTGGTTGCGCATACCATCCGTTTCGAAAGCGGAAATGAAATTATTCGAATCATCAGT
GCACGAAAAGCAGATCGTAAAGAGAGGAATCGCTATGAGCATGGTTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT164988 WP_001259255.1 NZ_CP057220:c2805815-2805564 [Escherichia fergusonii]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp

>AT164988 NZ_CP073624:c4193138-4192836 [Escherichia coli]
ATGAGCATGGTTAAACATAAACGAGGGACCTCCTCTACACTCGATGTGCAGCATGAGGCCGAACTGAAGGCGCTGACGAA
TAAATCCGACGAAGATATTGATTACAGTGATATCCCACCTTCCAGCGATGAGCAATGGTCTAACGCCGAACGCGGTAAGT
TTTATCGGCCATTGAAAACTCAGGCTTCGGTGCGTATTGATGCTGATGTGATGGAATGGTTGAAGCGACCAGGTAAAGGC
TATCAAACTCGCCTGAACGCAATTTTACGTGAAGCGATGCTGCGCGATCAGAACAAAAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6NY6
PDB 2A6S
PDB 6OXA
PDB 2A6R
PDB 4V8X
PDB 6OTR
PDB 6OXI
PDB 2A6Q

Antitoxin

Source ID Structure
PDB 2A6Q
AlphaFold DB A0A7U9LNR0

References