Detailed information of TA system TA164958

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 4491695..4491953
• Replicon: chromosome
• Accession: NZ_CP057215
• Organism: Escherichia fergusonii strain RHB33-C04

Toxin (Protein)

• Gene name: hokA
• Uniprot ID: -
• Locus tag: HVZ08_RS21805
• Protein ID: WP_001135723.1
• Coordinates: 4491695..4491847 (-)
• Length: 51 a.a.

Antitoxin (RNA)

Gene name	sokA
Locus tag	-
Coordinates	4491898..4491953 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HVZ08_RS21780	4487554..4488264	-	711	WP_000190514.1	DUF3053 domain-containing protein	-
HVZ08_RS21785	4488702..4490078	+	1377	WP_181666939.1	MFS transporter	-
HVZ08_RS21790	4490328..4490618	+	291	WP_000455800.1	HTH-type transcriptional regulator	-
HVZ08_RS21795	4490899..4491111	+	213	WP_000014594.1	RNA chaperone/antiterminator CspA	-
HVZ08_RS21800	4491165..4491536	-	372	WP_001037804.1	membrane protein insertion efficiency factor YidD	-
HVZ08_RS21805	4491695..4491847	-	153	WP_001135723.1	type I toxin-antitoxin system toxin HokA	Toxin
-	4491898..4491953	+	56	-	-	Antitoxin
HVZ08_RS21810	4492170..4494239	-	2070	WP_001291792.1	glycine--tRNA ligase subunit beta	-
HVZ08_RS21815	4494249..4495160	-	912	WP_001168544.1	glycine--tRNA ligase subunit alpha	-
HVZ08_RS21820	4495256..4495555	-	300	WP_181667494.1	YsaB family lipoprotein	-
HVZ08_RS21825	4495727..4496722	+	996	WP_002432855.1	acyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-46)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5899.14 Da
• Isoelectric Point: 6.9160

>T164958 WP_001135723.1 NZ_CP057215:c4491847-4491695 [Escherichia fergusonii]
MPQKYGLLSLIVICFTLLFFTWMIRDSLCELHIKQESYELAAFLACKLKE

Nucleotide

• Length: 153 bp

>T164958 NZ_CP073621:3402711-3403046 [Escherichia coli]
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCCGG
ACATCGTCCGGCTGTTGTCCTGAGTCCGTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTGTACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACGGTTGCCCCAGAGGAATTACAGCTCATTAAAGCCAAAATTAA
CGTGCTGATTGGGTAG

Antitoxin

Nucleotide

• Length: 56 bp

>AT164958 NZ_CP057215:4491898-4491953 [Escherichia fergusonii]
GTTGAAGCATAGAGGCAGCCTCACTTTGATTTATAGTCAGGTGGGGCTTTTCTCTG

Structures

Antitoxin