Detailed information of TA system TA164956

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): ldrD-sib/Ldr(toxin)
• Location: 4462427..4462646
• Replicon: chromosome
• Accession: NZ_CP057215
• Organism: Escherichia fergusonii strain RHB33-C04

Toxin (Protein)

• Gene name: ldrD
• Uniprot ID: S1NWX0
• Locus tag: HVZ08_RS21665
• Protein ID: WP_001295224.1
• Coordinates: 4462427..4462534 (-)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	sib
Locus tag	-
Coordinates	4462583..4462646 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HVZ08_RS21640	4457969..4458157	-	189	WP_001063310.1	YhjR family protein	-
HVZ08_RS21645	4458444..4460003	+	1560	WP_001070267.1	cellulose biosynthesis protein BcsE	-
HVZ08_RS21650	4460000..4460191	+	192	WP_000981122.1	cellulose biosynthesis protein BcsF	-
HVZ08_RS21655	4460188..4461867	+	1680	WP_000192007.1	cellulose biosynthesis protein BcsG	-
HVZ08_RS21660	4461954..4462061	-	108	WP_114091462.1	type I toxin-antitoxin system toxin Ldr family protein	-
HVZ08_RS21665	4462427..4462534	-	108	WP_001295224.1	type I toxin-antitoxin system toxin Ldr family protein	Toxin
-	4462583..4462646	+	64	NuclAT_12	-	Antitoxin
-	4462583..4462646	+	64	NuclAT_12	-	Antitoxin
-	4462583..4462646	+	64	NuclAT_12	-	Antitoxin
-	4462583..4462646	+	64	NuclAT_12	-	Antitoxin
-	4462583..4462646	+	64	NuclAT_13	-	Antitoxin
-	4462583..4462646	+	64	NuclAT_13	-	Antitoxin
-	4462583..4462646	+	64	NuclAT_13	-	Antitoxin
-	4462583..4462646	+	64	NuclAT_13	-	Antitoxin
-	4462583..4462646	+	64	NuclAT_14	-	Antitoxin
-	4462583..4462646	+	64	NuclAT_14	-	Antitoxin
-	4462583..4462646	+	64	NuclAT_14	-	Antitoxin
-	4462583..4462646	+	64	NuclAT_14	-	Antitoxin
-	4462583..4462646	+	64	NuclAT_15	-	Antitoxin
-	4462583..4462646	+	64	NuclAT_15	-	Antitoxin
-	4462583..4462646	+	64	NuclAT_15	-	Antitoxin
-	4462583..4462646	+	64	NuclAT_15	-	Antitoxin
-	4462583..4462648	+	66	NuclAT_10	-	-
-	4462583..4462648	+	66	NuclAT_10	-	-
-	4462583..4462648	+	66	NuclAT_10	-	-
-	4462583..4462648	+	66	NuclAT_10	-	-
-	4462583..4462648	+	66	NuclAT_11	-	-
-	4462583..4462648	+	66	NuclAT_11	-	-
-	4462583..4462648	+	66	NuclAT_11	-	-
-	4462583..4462648	+	66	NuclAT_11	-	-
HVZ08_RS21670	4462971..4464167	+	1197	WP_181666930.1	methionine gamma-lyase	-
HVZ08_RS21675	4464417..4465715	+	1299	WP_181666931.1	amino acid permease	-
HVZ08_RS21680	4465731..4466942	-	1212	WP_181666932.1	sigma 54-interacting transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Type I toxin-antitoxin system, toxin Ldr (1-35)

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 3882.70 Da
• Isoelectric Point: 9.0157

>T164956 WP_001295224.1 NZ_CP057215:c4462534-4462427 [Escherichia fergusonii]
MTLAELGMAFWHDLAAPVIAGILASMIVNWLNKRK

Nucleotide

• Length: 108 bp

>T164956 NZ_CP073621:c3156592-3156218 [Escherichia coli]
ATGAAAACATTACCTGACACACACGTACGGGAGGCATCGCGTTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCGC
CCGACTGCTGGACCAGCACTACGGCCTCACGCTGAATGACACTCCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCCGGCATTTCACTGTGCGATGCAGTGAACTTTCTTGTTGAAAAATACGAACTGGTGCGTACCGACCAGCCGGAATTC
AGTGCCTGTACCCGTTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin

Nucleotide

• Length: 64 bp

>AT164956 NZ_CP057215:4462583-4462646 [Escherichia fergusonii]
GTCTAGAGTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTT

Structures

Toxin

• AlphaFold DB: A0A4P7TSJ7

Antitoxin