Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 2781236..2781461 Replicon chromosome
Accession NZ_CP057215
Organism Escherichia fergusonii strain RHB33-C04

Toxin (Protein)


Gene name hokW Uniprot ID S1ELB5
Locus tag HVZ08_RS13445 Protein ID WP_000813254.1
Coordinates 2781236..2781391 (-) Length 52 a.a.

Antitoxin (RNA)


Gene name sokW
Locus tag -
Coordinates 2781403..2781461 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HVZ08_RS13390 2776819..2777037 - 219 WP_181666550.1 class II holin family protein -
HVZ08_RS13415 2777834..2778523 - 690 WP_096215950.1 antiterminator -
HVZ08_RS13420 2778520..2778885 - 366 WP_000139994.1 RusA family crossover junction endodeoxyribonuclease -
HVZ08_RS13425 2778886..2779941 - 1056 WP_181666551.1 DUF968 domain-containing protein -
HVZ08_RS13430 2779943..2780221 - 279 WP_097419052.1 hypothetical protein -
HVZ08_RS13435 2780337..2780822 - 486 WP_000818167.1 type II toxin-antitoxin system death-on-curing family toxin -
HVZ08_RS13440 2780841..2781020 - 180 WP_001277774.1 hypothetical protein -
HVZ08_RS13445 2781236..2781391 - 156 WP_000813254.1 type I toxin-antitoxin system toxin HokD Toxin
- 2781403..2781461 + 59 - - Antitoxin
HVZ08_RS13450 2781968..2782876 + 909 WP_001297700.1 bacteriophage abortive infection AbiH family protein -
HVZ08_RS13455 2782966..2784357 + 1392 WP_181666552.1 hypothetical protein -
HVZ08_RS13460 2784620..2785042 - 423 WP_162522223.1 DUF977 family protein -
HVZ08_RS13465 2785083..2786153 - 1071 WP_001262357.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2751624..2797256 45632


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(6-47)


Sequences

Toxin        


Download         Length: 52 a.a.        Molecular weight: 5736.89 Da        Isoelectric Point: 6.1531

>T164950 WP_000813254.1 NZ_CP057215:c2781391-2781236 [Escherichia fergusonii]
MKQQKAMLIALIVICLTVIVTALVTRKDLCEVRIRTGQTEVAVFTAYEPEE

Download         Length: 156 bp

>T164950 NZ_CP073621:c1785353-1785180 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin


Download         Length: 59 bp

>AT164950 NZ_CP057215:2781403-2781461 [Escherichia fergusonii]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTAGATTTGCCGTTCATAGATTGAGCCTCA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4P7TMW0

Antitoxin

Download structure file

References