Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 1010269..1010515 Replicon chromosome
Accession NZ_CP057215
Organism Escherichia fergusonii strain RHB33-C04

Toxin (Protein)


Gene name hokX Uniprot ID S1PD89
Locus tag HVZ08_RS04875 Protein ID WP_000956458.1
Coordinates 1010363..1010515 (+) Length 51 a.a.

Antitoxin (RNA)


Gene name sokX
Locus tag -
Coordinates 1010269..1010321 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HVZ08_RS04860 1005777..1007576 + 1800 WP_181667160.1 NADPH-dependent assimilatory sulfite reductase flavoprotein subunit -
HVZ08_RS04865 1007576..1009288 + 1713 WP_181667161.1 assimilatory sulfite reductase (NADPH) hemoprotein subunit -
HVZ08_RS04870 1009362..1010096 + 735 WP_046083134.1 phosphoadenosine phosphosulfate reductase -
- 1010269..1010321 - 53 - - Antitoxin
HVZ08_RS04875 1010363..1010515 + 153 WP_000956458.1 type I toxin-antitoxin system Hok family toxin Toxin
HVZ08_RS04880 1010751..1013408 + 2658 WP_002431960.1 CRISPR-associated helicase/endonuclease Cas3 -
HVZ08_RS04885 1013506..1015068 + 1563 WP_001084117.1 type I-E CRISPR-associated protein Cse1/CasA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(5-46)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5558.77 Da        Isoelectric Point: 7.6757

>T164939 WP_000956458.1 NZ_CP057215:1010363-1010515 [Escherichia fergusonii]
MLTKYALVAIIVLCCTVLGFTLMVGDSLCELSIRERGMEFKAVLAYESKK

Download         Length: 153 bp

>T164939 NZ_CP073590:83446-83595 [Escherichia coli]
ATGACGAAATATACCCTTATTGGGTTGCTCGCCGTGTGCGCCACGGTGTTGTGTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAGCTGAATATTCACAGGGGAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA

Antitoxin


Download         Length: 53 bp

>AT164939 NZ_CP057215:c1010321-1010269 [Escherichia fergusonii]
TTAGGTTCGAACGCTGGCCTCAGGTTGATAGAAATATCGCCTGGGGCTTTTGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4P7TJ83

Antitoxin

Download structure file

References