Detailed information of TA system TA164935

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 707590..707848
• Replicon: chromosome
• Accession: NZ_CP057215
• Organism: Escherichia fergusonii strain RHB33-C04

Toxin (Protein)

• Gene name: hokC
• Uniprot ID: -
• Locus tag: HVZ08_RS03495
• Protein ID: WP_000935262.1
• Coordinates: 707590..707799 (-)
• Length: 70 a.a.

Antitoxin (RNA)

Gene name	sokC
Locus tag	-
Coordinates	707791..707848 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HVZ08_RS03475	702656..703243	+	588	WP_002431696.1	molybdopterin adenylyltransferase	-
HVZ08_RS03480	703277..703843	-	567	WP_000528529.1	acetate uptake transporter	-
HVZ08_RS03485	704351..706267	+	1917	WP_000516135.1	molecular chaperone DnaK	-
HVZ08_RS03490	706356..707486	+	1131	WP_001118464.1	molecular chaperone DnaJ	-
HVZ08_RS03495	707590..707799	-	210	WP_000935262.1	type I toxin-antitoxin system Hok family toxin	Toxin
-	707791..707848	+	58	-	-	Antitoxin
HVZ08_RS03500	708283..709449	+	1167	WP_046076806.1	Na+/H+ antiporter NhaA	-
HVZ08_RS03505	709517..710416	+	900	WP_000019049.1	transcriptional activator NhaR	-
HVZ08_RS03510	710512..710775	-	264	WP_001274021.1	30S ribosomal protein S20	-
HVZ08_RS03515	710878..711096	+	219	WP_046076805.1	DUF2575 family protein	-
HVZ08_RS03520	711104..712045	+	942	WP_046081994.1	bifunctional riboflavin kinase/FAD synthetase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (25-66)

Sequences

Toxin

Protein

• Length: 70 a.a.
• Molecular weight: 7742.28 Da
• Isoelectric Point: 9.3680

>T164935 WP_000935262.1 NZ_CP057215:c707799-707590 [Escherichia fergusonii]
MLNTCRVPLTDRKVKEKRAMKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Nucleotide

• Length: 210 bp

>T164935 NZ_CP073589:c4311353-4311075 [Escherichia coli]
ATGATTCAAAGGGATATTGAATACTCGGGACAATTTTCAAAGGATGTAAAACTTGCACAAAAGCGTCATAAGGATATGAA
TAAATTGAAATATCTTATGACGCTTCTTATCAATAATGCTTTACCGCTTCCAGCTGTTTATAAAGACCACCCGCTGCAAG
GTTCATGGAAAGGTTATCGCGATGCTCATGTCGAACCGGACTGGATCCTGATTTACAAACTTACCGATAAACTTTTACGA
TTTGAGAGAACTGGAACTCACGCGGCGCTCTTTGGGTAA

Antitoxin

Nucleotide

• Length: 58 bp

>AT164935 NZ_CP057215:707791-707848 [Escherichia fergusonii]
GTTCAGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Structures

Antitoxin