Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yafN-yafO (relBE)/YafO-YafN
Location 3554505..3555199 Replicon chromosome
Accession NZ_CP057210
Organism Escherichia fergusonii strain RHB33-C07

Toxin (Protein)


Gene name yafO Uniprot ID -
Locus tag HVZ09_RS17235 Protein ID WP_181666723.1
Coordinates 3554505..3554903 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name yafN Uniprot ID -
Locus tag HVZ09_RS17240 Protein ID WP_181666724.1
Coordinates 3554906..3555199 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HVZ09_RS17205 3549633..3551090 + 1458 WP_001293012.1 cytosol nonspecific dipeptidase -
HVZ09_RS17210 3551099..3551380 + 282 WP_000106440.1 hypothetical protein -
HVZ09_RS17215 3551389..3551913 - 525 WP_141095971.1 metal-dependent hydrolase -
HVZ09_RS17220 3551975..3552589 - 615 WP_046076930.1 peptide chain release factor H -
HVZ09_RS17225 3552586..3553725 - 1140 WP_181666722.1 RNA ligase RtcB family protein -
HVZ09_RS17230 3554043..3554495 - 453 WP_001059848.1 GNAT family N-acetyltransferase -
HVZ09_RS17235 3554505..3554903 - 399 WP_181666723.1 type II toxin-antitoxin system mRNA interferase toxin YafO Toxin
HVZ09_RS17240 3554906..3555199 - 294 WP_181666724.1 type I toxin-antitoxin system antitoxin YafN Antitoxin
HVZ09_RS17245 3555251..3556306 - 1056 WP_001226157.1 DNA polymerase IV -
HVZ09_RS17250 3556377..3557162 - 786 WP_181666725.1 putative lateral flagellar export/assembly protein LafU -
HVZ09_RS17255 3557107..3558846 + 1740 WP_181666726.1 flagellar biosynthesis protein FlhA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin YafO

(27-130)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 15516.93 Da        Isoelectric Point: 8.9401

>T164912 WP_181666723.1 NZ_CP057210:c3554903-3554505 [Escherichia fergusonii]
MRVFKTKLIRLQLTAKELDALTADFISYKRDSVLPDIFGRDALYDDSFTWPLIKFERVAHIHLANENNPFPPQLRQFSRT
NDEAHLVYCQGAFDEQAWLLIAILKPEPHKLARDNNQMHKIGKMAEAFRMRF

Download         Length: 399 bp

>T164912 NZ_CP073586:c2457842-2457543 [Proteiniphilum propionicum]
ATGAAATTTGAAATAAGCGAAAAAGCATTTGAGGATATTGAAAATATTTGGCTATACACAATTGAATCCTGGTCAGTTGA
ACAGGCTGATCGATATTTTAATTTGCTTCTTGACGAGATTGAATATATCACAGAACATCCTTTATCTGAAAAAAATGCTG
ACCACATAAGAAAAAACTACAGGTATACAAAGGTTAAGTCACATTTGGTATTTTACAGATACAAGAAGTCGGAGAAAAAA
GTGGAAATAATAAGAATACTCCACCATAGTATGGATGTAGAAGAGCGAATGAATGAATGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11267.82 Da        Isoelectric Point: 5.9050

>AT164912 WP_181666724.1 NZ_CP057210:c3555199-3554906 [Escherichia fergusonii]
MHRILAEKSVNITELRKNPAKYFIDQPVAVLSNNRPAGYLLSASAFEALMDMLAEQEEKKPIKARFRPSAARLEEITRRA
EKYFNDMTDDDFNDFKE

Download         Length: 294 bp

>AT164912 NZ_CP073586:c2458086-2457832 [Proteiniphilum propionicum]
ATGGCAAAGAATACATCAATTTTACTCGGCGAGTATTTCGAGAATTTTATAAACGAGAAAGTTAAATCAGGTAAGTTTGC
ATCTGCAAGTGAAGTCGTAAGAACAGCTTTACGGTTGTTTGAACAACAAGAGAACAAGACAAAAATTCTTGTAAATGAGT
TGAAAGCAGGAGAAGAATCGGGAATGATTAGCAATTTTGACAGAGAAAAAGCACTTTCCAATCTTCACACCAAATACCTG
CACAATGAAATTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References