Detailed information of TA system TA164909

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 2781236..2781461
• Replicon: chromosome
• Accession: NZ_CP057210
• Organism: Escherichia fergusonii strain RHB33-C07

Toxin (Protein)

• Gene name: hokW
• Uniprot ID: S1ELB5
• Locus tag: HVZ09_RS13470
• Protein ID: WP_000813254.1
• Coordinates: 2781236..2781391 (-)
• Length: 52 a.a.

Antitoxin (RNA)

Gene name	sokW
Locus tag	-
Coordinates	2781403..2781461 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HVZ09_RS13415	2776819..2777037	-	219	WP_181666550.1	class II holin family protein	-
HVZ09_RS13440	2777834..2778523	-	690	WP_096215950.1	antiterminator	-
HVZ09_RS13445	2778520..2778885	-	366	WP_000139994.1	RusA family crossover junction endodeoxyribonuclease	-
HVZ09_RS13450	2778886..2779941	-	1056	WP_181666551.1	DUF968 domain-containing protein	-
HVZ09_RS13455	2779943..2780221	-	279	WP_097419052.1	hypothetical protein	-
HVZ09_RS13460	2780337..2780822	-	486	WP_000818167.1	type II toxin-antitoxin system death-on-curing family toxin	-
HVZ09_RS13465	2780841..2781020	-	180	WP_001277774.1	hypothetical protein	-
HVZ09_RS13470	2781236..2781391	-	156	WP_000813254.1	type I toxin-antitoxin system toxin HokD	Toxin
-	2781403..2781461	+	59	-	-	Antitoxin
HVZ09_RS13475	2781968..2782876	+	909	WP_001297700.1	bacteriophage abortive infection AbiH family protein	-
HVZ09_RS13480	2782966..2784357	+	1392	WP_181666552.1	hypothetical protein	-
HVZ09_RS13485	2784620..2785042	-	423	WP_162522223.1	DUF977 family protein	-
HVZ09_RS13490	2785083..2786153	-	1071	WP_001262357.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2751624..2797256	45632

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-47)

Sequences

Toxin

Protein

• Length: 52 a.a.
• Molecular weight: 5736.89 Da
• Isoelectric Point: 6.1531

>T164909 WP_000813254.1 NZ_CP057210:c2781391-2781236 [Escherichia fergusonii]
MKQQKAMLIALIVICLTVIVTALVTRKDLCEVRIRTGQTEVAVFTAYEPEE

Nucleotide

• Length: 156 bp

>T164909 NZ_CP073578:c1375800-1375531 [Photobacterium sp. GJ3]
ATGAGTCATAGCCAACGTTTACTAACATGGACTGATGAAGCTTGGGGTGACTACCTATACTGGCAAACCCAAGACAAAAA
GACACTGAAGCGAATAAATAAATTAATCAACGATGTAAAGCGTTCACCATTTGAAGGGATTGGTAAGCCCGAGCCCTTAA
AGGAGAACTTATCTGGTTTTTGGTCGCGCCGTATTGATGATACAAATCGGCTAGTTTACGCAGTTGATCATCAAGCGATT
ACGATTATTTCATGTCGCTATCACTACTAA

Antitoxin

Nucleotide

• Length: 59 bp

>AT164909 NZ_CP057210:2781403-2781461 [Escherichia fergusonii]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTAGATTTGCCGTTCATAGATTGAGCCTCA

Structures

Toxin

• AlphaFold DB: A0A4P7TMW0

Antitoxin