Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 577756..578555 Replicon chromosome
Accession NZ_CP057210
Organism Escherichia fergusonii strain RHB33-C07

Toxin (Protein)


Gene name yhaV Uniprot ID U9XVR9
Locus tag HVZ09_RS02745 Protein ID WP_000347267.1
Coordinates 577756..578220 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID B7LMV4
Locus tag HVZ09_RS02750 Protein ID WP_015953962.1
Coordinates 578220..578555 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HVZ09_RS02715 572758..573192 - 435 WP_181667088.1 PTS sugar transporter subunit IIA -
HVZ09_RS02720 573210..574088 - 879 WP_001295548.1 PTS system mannose/fructose/sorbose family transporter subunit IID -
HVZ09_RS02725 574078..574857 - 780 WP_000406214.1 PTS mannose/fructose/sorbose/N-acetylgalactosamine transporter subunit IIC -
HVZ09_RS02730 574868..575341 - 474 WP_181667089.1 PTS N-acetylgalactosamine transporter subunit IIB -
HVZ09_RS02735 575364..576644 - 1281 WP_180491940.1 tagatose-bisphosphate aldolase subunit KbaZ -
HVZ09_RS02740 576892..577701 + 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
HVZ09_RS02745 577756..578220 - 465 WP_000347267.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
HVZ09_RS02750 578220..578555 - 336 WP_015953962.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
HVZ09_RS02755 578704..580275 - 1572 WP_181667090.1 galactarate dehydratase -
HVZ09_RS02760 580746..581516 + 771 WP_001058567.1 2-dehydro-3-deoxyglucarate aldolase -
HVZ09_RS02765 581541..582431 + 891 WP_000178100.1 2-hydroxy-3-oxopropionate reductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17807.17 Da        Isoelectric Point: 9.4947

>T164893 WP_000347267.1 NZ_CP057210:c578220-577756 [Escherichia fergusonii]
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWESLTQETEENH

Download         Length: 465 bp

>T164893 NZ_CP073377:1673483-1673585 [Klebsiella sp. P1927]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12281.89 Da        Isoelectric Point: 4.4128

>AT164893 WP_015953962.1 NZ_CP057210:c578555-578220 [Escherichia fergusonii]
MPANARSNAVLTTESKVTIRGQTTIPAPVREALKLKPGLDSIHYEILPGGQVFMCRLGDEQEDPTMNAFLRFLDADIQNN
PQKTRPFDIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp

>AT164893 NZ_CP073377:c1673592-1673447 [Klebsiella sp. P1927]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0XTR4

Antitoxin

Source ID Structure
AlphaFold DB B7LMV4

References