Detailed information of TA system TA164890

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): prlF-yhaV (relBE)/YhaV-PrlF
• Location: 4223088..4223903
• Replicon: chromosome
• Accession: NZ_CP057150
• Organism: Citrobacter sp. RHB35-C17

Toxin (Protein)

• Gene name: yhaV
• Uniprot ID: -
• Locus tag: HVZ37_RS20150
• Protein ID: WP_181627920.1
• Coordinates: 4223088..4223564 (-)
• Length: 159 a.a.

Antitoxin (Protein)

• Gene name: prlF
• Uniprot ID: A0A3Q8DNJ3
• Locus tag: HVZ37_RS20155
• Protein ID: WP_042999108.1
• Coordinates: 4223568..4223903 (-)
• Length: 112 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HVZ37_RS20130	4218193..4218936	-	744	WP_044264050.1	molecular chaperone	-
HVZ37_RS20135	4218979..4221453	-	2475	WP_044257386.1	fimbria/pilus outer membrane usher protein	-
HVZ37_RS20140	4221517..4221966	-	450	WP_099433589.1	type 1 fimbrial protein	-
HVZ37_RS20145	4222134..4222664	-	531	WP_042999110.1	type 1 fimbrial protein	-
HVZ37_RS20150	4223088..4223564	-	477	WP_181627920.1	type II toxin-antitoxin system YhaV family toxin	Toxin
HVZ37_RS20155	4223568..4223903	-	336	WP_042999108.1	type II toxin-antitoxin system PrlF family antitoxin	Antitoxin
HVZ37_RS20160	4224118..4224654	-	537	WP_042999107.1	ferredoxin-type protein NapF	-
HVZ37_RS20165	4224651..4225247	-	597	WP_181627921.1	molecular chaperone	-
HVZ37_RS20170	4225292..4226065	-	774	WP_054176703.1	dimethyl sulfoxide reductase anchor subunit	-
HVZ37_RS20175	4226058..4226684	-	627	WP_042999104.1	dimethylsulfoxide reductase subunit B	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin endonuclease, YhaV (12-150)

Antitoxin

• PrlF antitoxin (15-110)

Sequences

Toxin

Protein

• Length: 159 a.a.
• Molecular weight: 18266.84 Da
• Isoelectric Point: 7.9064

>T164890 WP_181627920.1 NZ_CP057150:c4223564-4223088 [Citrobacter sp. RHB35-C17]
MDFPTWLNGWTIYAHPCFIDQYNALVARVEDLKHRFPDPIVFQKKKETKVLAHLLKSIANITHEPRASVYRPGDSIGKAY
TDWSRAEFGGGRYRLFFRYSLESKIIVIAWVNDEGPLRTYGSKTDAYKIFGKMLDEGNPPDDWLSLLQVCQNDGKEHL

Nucleotide

• Length: 477 bp

>T164890 NZ_CP073377:7021-7368 [Klebsiella sp. P1927]
ATGTGGGATGTAGAAACGACGGATACGTTTGATGCCTGGTTCGAATTACAAAGTAGAGCTTTAAAAGAGGATATGTTGGC
CACGATGCTCATCCTGTCTGAGTTTGCTCCGCAGCTTGGGCGCCCGTATGTTGATACGGTGAAAGATTCAACGTTTCAGA
ATATGAAAGAACTGCGGGTTCAGCATCATGGGCTCCCCATCCGCGCCTGTTTTGCTTTTGATCCTCTGCGGAAAGCTATC
GTTTTATGTGTGGGCAATAAGGATGGCATGAATGAGAAACGTTTTTACAAAGAGATGATTACTCTGGCTGACAGAGAATT
CAGCCAACACCTGACTAAGGAGCGATAA

Antitoxin

Protein

• Length: 112 a.a.
• Molecular weight: 12505.83 Da
• Isoelectric Point: 4.1876

>AT164890 WP_042999108.1 NZ_CP057150:c4223903-4223568 [Citrobacter sp. RHB35-C17]
MFAYVRSEDIAIEADSKLTERHQTTIPASIRDALHLRSGDRIHYTLLSTGEVLLSKYSEATEDGVMRSFLDFLSQDVANN
PQTLKKLDLSRGYELVDGIDVNLDDEISDED

Nucleotide

• Length: 336 bp

>AT164890 NZ_CP073377:7368-7667 [Klebsiella sp. P1927]
ATGGCCACGCTAAAAGAACTCATGGCGAAACAGAGTCCTGATAGCCAGCAGCGTATTGCAGCGAAAGCGGCAGAGATACG
CCAGTCTGTCGCTTTAAACTTGCTTCGAGAAGAGTTGCAAATGTCGCAAACAGAGATGGCTGCGGCTATGGGGGTAAAGC
AGCCAACGATCGCTAAAATGGAACAGGCTGATAACGACCCTCGGCTTTCGACCCTAAAACGCTACATTGCGGCATTGGGG
GGAGAACTCAGTATAAATGTCACATTGCCGACTGGAAAAAAAGTCTCGTTTAATTTGTGA

Structures

Antitoxin

• AlphaFold DB: A0A3Q8DNJ3