Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 2284672..2285234 Replicon chromosome
Accession NZ_CP057150
Organism Citrobacter sp. RHB35-C17

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag HVZ37_RS10815 Protein ID WP_181628427.1
Coordinates 2284672..2284950 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag HVZ37_RS10820 Protein ID WP_043000693.1
Coordinates 2284950..2285234 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HVZ37_RS10795 2279797..2280228 - 432 WP_043000697.1 peroxiredoxin OsmC -
HVZ37_RS10800 2280456..2280599 + 144 WP_042319017.1 stationary-phase-induced ribosome-associated protein -
HVZ37_RS10805 2280771..2282468 + 1698 WP_044257943.1 malate dehydrogenase -
HVZ37_RS10810 2282777..2284492 + 1716 WP_181628426.1 ATP-binding cassette domain-containing protein -
HVZ37_RS10815 2284672..2284950 + 279 WP_181628427.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HVZ37_RS10820 2284950..2285234 + 285 WP_043000693.1 HigA family addiction module antidote protein Antitoxin
HVZ37_RS10825 2285279..2285881 - 603 WP_142765134.1 inorganic diphosphatase -
HVZ37_RS10830 2286008..2286664 - 657 WP_043000691.1 formate dehydrogenase-N subunit gamma -
HVZ37_RS10835 2286657..2287541 - 885 WP_043000690.1 formate dehydrogenase subunit beta -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-83)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10631.16 Da        Isoelectric Point: 8.1124

>T164879 WP_181628427.1 NZ_CP057150:2284672-2284950 [Citrobacter sp. RHB35-C17]
MIMNFRHKGLRDLFLHGKTSGVLAKHVKRLRHRLAVIDAAGCVNDINMPGYRLHPLSGDRDGVWSISVSDNWRMTFEFVN
GDAYILDYEDYH

Download         Length: 279 bp

>T164879 NZ_CP073373:1698110-1698328 [Klebsiella sp. P1954]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACCTCTGTCTGGAAATTTATCCGCTAA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10370.07 Da        Isoelectric Point: 10.2982

>AT164879 WP_043000693.1 NZ_CP057150:2284950-2285234 [Citrobacter sp. RHB35-C17]
MKMANHPRPGDIIQEALDELNVSLREFARAMEIAPSTASRLLTGKAALTPEMAIKLSVVIGSSPEMWLNLQNTWSLAQAQ
KSVDVSRLRRLAVQ

Download         Length: 285 bp

>AT164879 NZ_CP073373:1697709-1698083 [Klebsiella sp. P1954]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCAGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References