Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4862385..4862984 Replicon chromosome
Accession NZ_CP057136
Organism Citrobacter freundii strain RHB36-C06

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag HVZ46_RS22975 Protein ID WP_181618147.1
Coordinates 4862673..4862984 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag HVZ46_RS22970 Protein ID WP_079939299.1
Coordinates 4862385..4862672 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HVZ46_RS22955 4859881..4860783 + 903 WP_115259809.1 formate dehydrogenase O subunit beta -
HVZ46_RS22960 4860780..4861415 + 636 WP_096758858.1 formate dehydrogenase cytochrome b556 subunit -
HVZ46_RS22965 4861412..4862341 + 930 WP_096758859.1 formate dehydrogenase accessory protein FdhE -
HVZ46_RS22970 4862385..4862672 - 288 WP_079939299.1 helix-turn-helix domain-containing protein Antitoxin
HVZ46_RS22975 4862673..4862984 - 312 WP_181618147.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HVZ46_RS22980 4863205..4864134 + 930 WP_181618148.1 alpha/beta hydrolase -
HVZ46_RS22985 4864220..4864531 + 312 WP_181618149.1 type II toxin-antitoxin system HigB family toxin -
HVZ46_RS22990 4864528..4864974 + 447 WP_181618150.1 helix-turn-helix domain-containing protein -
HVZ46_RS22995 4864989..4865930 - 942 WP_181618151.1 fatty acid biosynthesis protein FabY -
HVZ46_RS23000 4865975..4866412 - 438 WP_181618152.1 D-tyrosyl-tRNA(Tyr) deacylase -
HVZ46_RS23005 4866409..4867281 - 873 WP_181618153.1 virulence factor BrkB family protein -
HVZ46_RS23010 4867275..4867874 - 600 WP_181618154.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12263.39 Da        Isoelectric Point: 10.0972

>T164853 WP_181618147.1 NZ_CP057136:c4862984-4862673 [Citrobacter freundii]
MLFIETEIFTEDVKKLLDDDEYRRLQIFLTIQPDCGDLIQDIGGLRKVRWRARGKGKRGGVRIIYFHQIRKSQIRLLLIY
QKGIKDDLTSQEKVLLRMLNEGW

Download         Length: 312 bp

>T164853 NZ_CP073360:194224-194331 [Escherichia coli]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAATAAGCGGAAGTAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10775.39 Da        Isoelectric Point: 11.1842

>AT164853 WP_079939299.1 NZ_CP057136:c4862672-4862385 [Citrobacter freundii]
MDKALFERLTQSMIQMNEIAEGTRQPSRTFHIDAMKIKEIRQSSGLSQTRFADLISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPKHVIQALR

Download         Length: 288 bp

>AT164853 NZ_CP073360:c194167-194112 [Escherichia coli]
TCAAGATTAGCCCCCGTTATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References