Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 32780..33430 Replicon chromosome
Accession NZ_CP057136
Organism Citrobacter freundii strain RHB36-C06

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag HVZ46_RS00165 Protein ID WP_181618247.1
Coordinates 32780..33121 (+) Length 114 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag HVZ46_RS00170 Protein ID WP_181618248.1
Coordinates 33131..33430 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HVZ46_RS00145 29179..30570 + 1392 WP_181618243.1 hexose-6-phosphate:phosphate antiporter -
HVZ46_RS00150 30614..31519 - 906 WP_181618244.1 LysR family transcriptional regulator -
HVZ46_RS00155 31625..32077 + 453 WP_181618245.1 DUF1198 family protein -
HVZ46_RS00160 32177..32701 + 525 WP_181618246.1 SRPBCC domain-containing protein -
HVZ46_RS00165 32780..33121 + 342 WP_181618247.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HVZ46_RS00170 33131..33430 + 300 WP_181618248.1 helix-turn-helix transcriptional regulator Antitoxin
HVZ46_RS00175 33550..34743 + 1194 WP_181618249.1 purine ribonucleoside efflux pump NepI -
HVZ46_RS00180 34851..36227 - 1377 WP_181618250.1 carbohydrate porin -
HVZ46_RS00185 36435..36737 - 303 WP_008786514.1 PTS lactose/cellobiose transporter subunit IIA -
HVZ46_RS00190 36750..38132 - 1383 WP_181618251.1 glycoside hydrolase family 1 protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-107)

Antitoxin

Cro/C1-type helix-turn-helix domain

(31-84)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 13011.86 Da        Isoelectric Point: 6.2275

>T164833 WP_181618247.1 NZ_CP057136:32780-33121 [Citrobacter freundii]
MWDVETTDAFDKWFDVQTEALKEDMLAAMMILSEYGPQLGRPFADTVNDSAFSNMKELRVQHQGNPIRAFFAFDPSRHGI
VLCAGGKTGINEKKFYKDMIKFADVEYRKHLNK

Download         Length: 342 bp

>T164833 NZ_CP073351:2002187-2002289 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10916.82 Da        Isoelectric Point: 10.0948

>AT164833 WP_181618248.1 NZ_CP057136:33131-33430 [Citrobacter freundii]
MATLKELMAKQSPKSQERIAEKVEVLRQAVALSMLREELNLSQAELASVMGVKQPTIAKMEQADNDPRLSTLKRYVAALG
GELSIDVKLPTGKRVAFHL

Download         Length: 300 bp

>AT164833 NZ_CP073351:c2002296-2002151 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References