164819

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 43316..43965 Replicon chromosome
Accession NZ_CP057125
Organism Citrobacter sp. RHB36-C18

Toxin (Protein)


Gene name higB Uniprot ID A0A7L6TVT2
Locus tag HVZ52_RS00205 Protein ID WP_016157800.1
Coordinates 43316..43657 (+) Length 114 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A7L6TWH1
Locus tag HVZ52_RS00210 Protein ID WP_016157799.1
Coordinates 43666..43965 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HVZ52_RS00190 39752..41080 + 1329 WP_049042685.1 MFS transporter -
HVZ52_RS00195 41223..42614 + 1392 WP_003023929.1 hexose-6-phosphate:phosphate antiporter -
HVZ52_RS00200 42763..43215 + 453 WP_016157801.1 DUF1198 family protein -
HVZ52_RS00205 43316..43657 + 342 WP_016157800.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HVZ52_RS00210 43666..43965 + 300 WP_016157799.1 helix-turn-helix transcriptional regulator Antitoxin
HVZ52_RS00215 44084..45268 + 1185 WP_016155040.1 purine ribonucleoside efflux pump NepI -
HVZ52_RS00220 45324..46706 - 1383 WP_016157797.1 glycoside hydrolase family 1 protein -
HVZ52_RS00225 46799..47092 - 294 WP_019078023.1 hypothetical protein -
HVZ52_RS00230 47223..47639 + 417 WP_019078024.1 GNAT family N-acetyltransferase -
HVZ52_RS00235 47811..48629 + 819 WP_016157795.1 lipoprotein NlpA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-107)

Antitoxin

HigA2-like, helix-turn-helix domain

(8-88)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 13061.92 Da        Isoelectric Point: 5.6550

>T164819 WP_016157800.1 NZ_CP057125:43316-43657 [Citrobacter sp. RHB36-C18]
MWEVETTDVFDKWFDVQTEALKEDMLAAMMILSEYGPQLGRPFADTVNASAFSNMKELRVQHQGNPIRAFFVFDPSRHGI
VLCAGDKTGLNEKKFYKEMIRLADAEYRNHLNK

Download         Length: 342 bp

>T164819 NZ_CP073317:c173721-173614 [Lacticaseibacillus rhamnosus]
TTGCGTGTTGCTCCTGATTGGCTTCTCGTTTATAAAGTCGATGCTGAAGCGTTAATTTTAATGCTTCTTGCAACAGGCAC
ACACCGCGATACATTGAACATTGAGTAA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10988.84 Da        Isoelectric Point: 8.6007

>AT164819 WP_016157799.1 NZ_CP057125:43666-43965 [Citrobacter sp. RHB36-C18]
MATLKELMAKQSPESQERIAEKVEVLRQVIALNMLREELNLSQAELASAMGVKQPTIAKMEQADNDPRLSTLKRYVTALG
GELSIDVKLPTGKRVAFHL

Download         Length: 300 bp

>AT164819 NZ_CP073317:c174099-173827 [Lacticaseibacillus rhamnosus]
ATGGCAAAAGAATCCCGTATCCGCAATTGGATTAACACAATAACCAGAAAACGAGCTCTCCATGTTCTTAATCGTCTGGG
ACTAGAGAGATTCTCGGCTATTAACATGTATTGGAAACGGATTGGTGACACCGGTGCATTGCCATTTACACTTGAAATGT
CATTCGCCGATCAGCTTCGATTTGCAGAAGCAGATGTTAAAGCGGGGCGAATAAAAAGCTTCAAGACTGTTGGTGCTTTG
ATGAAGGATTTATACAGTGATGTTGACGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7L6TVT2

Antitoxin

Source ID Structure
AlphaFold DB A0A7L6TWH1

References