Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yafN-yafO (relBE)/YafO-YafN
Location 3495544..3496238 Replicon chromosome
Accession NZ_CP057104
Organism Escherichia fergusonii strain RHB38-C01

Toxin (Protein)


Gene name yafO Uniprot ID -
Locus tag HVZ66_RS17020 Protein ID WP_181199277.1
Coordinates 3495544..3495942 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name yafN Uniprot ID -
Locus tag HVZ66_RS17025 Protein ID WP_046080635.1
Coordinates 3495945..3496238 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HVZ66_RS16990 3490670..3492127 + 1458 WP_001293009.1 cytosol nonspecific dipeptidase -
HVZ66_RS16995 3492136..3492417 + 282 WP_000106440.1 hypothetical protein -
HVZ66_RS17000 3492426..3492950 - 525 WP_181591586.1 metal-dependent hydrolase -
HVZ66_RS17005 3493013..3493627 - 615 WP_181590732.1 peptide chain release factor H -
HVZ66_RS17010 3493624..3494763 - 1140 WP_181590733.1 RNA ligase RtcB family protein -
HVZ66_RS17015 3495082..3495534 - 453 WP_001059848.1 GNAT family N-acetyltransferase -
HVZ66_RS17020 3495544..3495942 - 399 WP_181199277.1 type II toxin-antitoxin system mRNA interferase toxin YafO Toxin
HVZ66_RS17025 3495945..3496238 - 294 WP_046080635.1 type I toxin-antitoxin system antitoxin YafN Antitoxin
HVZ66_RS17030 3496290..3497345 - 1056 WP_181590734.1 DNA polymerase IV -
HVZ66_RS17035 3497416..3498339 - 924 WP_161397365.1 putative lateral flagellar export/assembly protein LafU -
HVZ66_RS17040 3498342..3499205 - 864 WP_001169517.1 flagellar motor stator protein MotA -
HVZ66_RS17045 3499218..3499934 - 717 WP_181590735.1 FliA/WhiG family RNA polymerase sigma factor -
HVZ66_RS17050 3499954..3500421 - 468 WP_000725254.1 flagellar basal body-associated FliL family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin YafO

(27-130)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 15530.91 Da        Isoelectric Point: 8.0934

>T164804 WP_181199277.1 NZ_CP057104:c3495942-3495544 [Escherichia fergusonii]
MRVFKTKLIRLQLTDKELDALTADFISYKRDGVLPDIFGRDALYDDSFTWPLIKFERVAHIHLANENNPFPPQLRQFSRT
NDEAHLVYCQGAFDEQAWLLIAILKPEPHKLARDNNQMHKIGKMAEAFRMRF

Download         Length: 399 bp

>T164804 NZ_CP073303:c69501-69085 [Klebsiella pneumoniae]
GTGAACAAGACCTATATGCTCGACACCTGTATCTGCTCGTTCATCATGCGCGAGCAGCCGGAAGCCGTCCTGAAGCGCCT
GGAGCAGGCGGTGCTGCGCGGCCAGCGCATCGTTGTCTCGGCCATCACTTATTCTGAAATGCGCTTCGGGGCCACCGGCC
CGAAGGCCTCCCCGCGCCACGTCGAGCTGGTCGACGCGTTCTGCGCCCGCCTCGATGCCATCCTGCCCTGGGATCGCGCT
GCGGTGGACGCCACCACGGAGATTAAGGTGGCGCTGCGAATGGCCGGGACGCCGATCGGCCCGAACGACACGGCCATTGC
CGGGCACGCCATCGCCGCCGGTGCCGTGCTGGTGACGAATAATACGCGGGAATTTGAGCGGGTACCGGGTCTTGTGCTGG
AAGACTGGGTAAGATAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11223.72 Da        Isoelectric Point: 5.2170

>AT164804 WP_046080635.1 NZ_CP057104:c3496238-3495945 [Escherichia fergusonii]
MHRILAEKSVNITELRKNPAKYFIDQPVAVLSNNRPAGYLLSASAFEALMDMLAEQEEKKSIKARFRPSAARLEEITRRA
EQYLNDMTDDDFNDFKE

Download         Length: 294 bp

>AT164804 NZ_CP073303:c69728-69498 [Klebsiella pneumoniae]
ATGAGAACTGTATCCATTTTTAAAAACGGCAATAACCGCGCCATTCGTCTGCCCCGCGATCTGGATTTTGAGGGAGTGAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATTATTTTGCGTCCCGTCCGGCCGACCTGGGGCTCGTTCGCGCAGTTCG
AGAAGGCAGACCCGGACTTTATGGCGGAGCGCGAGGACGTTGTCAGCGACGAAGGACGATTTAACCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References